Document Detail

Hypothesis: link between endogenous retroviruses and cardiovascular disease.
MedLine Citation:
PMID:  9710794     Owner:  NLM     Status:  MEDLINE    
A two-order-magnitude increase in the expression of an endogenous retrovirus was found in myocytes from spontaneously hypertensive rats (SHR) relative to Wistar-Kyoto rats (WKY). It has now been demonstrated that the increase in proviral transcripts is not secondary to the effects of pressure overload, as WKY hearts with hypertrophy due to aortic banding do not express the retrovirus. Crossing SHR with WKY results in intermediate levels of blood pressure, hypertrophy and retroviral gene expression, suggesting co-segregation of genotype and phenotype. Findings suggest a possible linkage between an endogenous retrovirus and genetic hypertension in the SHR. A brief overview of endogenous retroviruses is presented and a discussion of their potential for inducing cardiovascular pathology is considered.
O H Bing; G Sirokman; D E Humphries
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  30     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1257-62     Citation Subset:  IM    
Department of Veterans Affairs Medical Center, Boston, MA 02130, USA.
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MeSH Terms
Cardiovascular Diseases / virology*
DNA Transposable Elements
Rats, Inbred SHR
Retroviridae / genetics,  physiology*
Reg. No./Substance:
0/DNA Transposable Elements

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