| Hypothesis: a damaging role in aging for reactive protein oxidation products? | |
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MedLine Citation:
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PMID: 1383779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role. |
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Authors:
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R T Dean; J Gebicki; S Gieseg; A J Grant; J A Simpson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mutation research Volume: 275 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-23 Completed Date: 1992-11-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 387-93 Citation Subset: IM |
Affiliation:
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Cell Biology Group, Heart Research Institute, Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Arteriosclerosis / etiology, physiopathology DNA Damage* Free Radicals Humans Models, Biological Oxidation-Reduction Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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