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Hypothesis: Terminal transverse limb defects with "nubbins" represent a regenerative process during limb development in human fetuses.
MedLine Citation:
PMID:  22287196     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Terminal transverse limb defects with nubbins occur in one arm at one of several levels (distal humerus, proximal forearm, wrist, and at the metacarpal-phalangeal joint in the hand). The associated nubbins contain osteocartilaginous tissue and small nails and are not associated with evidence of amnion disruption. METHODS: We present affected newborn infants whose terminal transverse limb defects are at one of these three levels: proximal forearm, elbow, or metacarpal-phalangeal joint. RESULTS: We hypothesize that the presence of residual digit-like structures reflects a regenerative process that has occurred during limb development in these infants. DISCUSSION: Only limited regeneration of digit-like structures can occur in the human fetus. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
Authors:
David M Gardiner; Lewis B Holmes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-30
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  -     ISSN:  1542-0760     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Developmental and Cell Biology, University of California Irvine, Irvine, Calif.
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