Document Detail


Hypothesis on the relationship between the change in intracellular pH and incidence of sporadic Alzheimer's disease or vascular dementia.
MedLine Citation:
PMID:  20707633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to perform their normal physiological functions, it is important that cells maintain the intracellular pH within the physiological range. Intracellular enzyme activity, cytoskeleton component integration, and cellular growth and differentiation rates are all closely associated with the intracellular pH. It has been demonstrated that in nervous system diseases, such as ischemic stroke, traumatic brain injury, epilepsy, Parkinson's disease, and Alzheimer's disease (AD), the common characteristics are decreased pH or acidosis at both tissular and cellular levels. Particularly, some AD-associated enzymes will have altered activities under acidic conditions. We inferred that aging or ischemia may cause intracellular acidification. This acidification not only induces apoptosis but also substantially alters enzyme activities and promotes the development of AD or vascular dementia. The hypothesis of an intracellular pH role in sporadic AD or vascular dementia will be discussed in this paper. If confirmed, this hypothesis may lead to the formulation of new pathogenesis and new therapeutic approaches to AD or vascular dementia.
Authors:
Boyan Fang; Dajiang Wang; Meifeng Huang; Guohua Yu; Hua Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, China. fangboyanv@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Alzheimer Disease / etiology*,  metabolism,  physiopathology
Amyloid beta-Peptides / metabolism
Dementia, Vascular / etiology*,  metabolism,  physiopathology
Humans
Hydrogen-Ion Concentration
Intracellular Fluid / chemistry
Ischemia / metabolism
Chemical
Reg. No./Substance:
0/Amyloid beta-Peptides

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