| Hypothermia for perinatal asphyxial encephalopathy. | |
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MedLine Citation:
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PMID: 21328098 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Perinatal asphyxial encephalopathy occurs in 1 per 1000 live births and is associated with high mortality and morbidity. Therapeutic hypothermia increases intact survival and improves neurodevelopmental outcome in survivors. AIMS: To evaluate (i) the opinion and practice of therapeutic hypothermia as a therapy for moderate to severe perinatal asphyxial encephalopathy amongst Swiss neonatologists and paediatric intensive care specialists, (ii) the current clinical management of infants with perinatal asphyxial encephalopathy and (iii) the need for a national perinatal asphyxia and therapeutic hypothermia registry. METHODS: Two web-based questionnaires were sent to 18 senior staff physicians within the Swiss Neonatal Network. RESULTS: Therapeutic hypothermia was considered effective by all responders, however only 11 of 18 units provided therapeutic hypothermia. Cooling was initiated during transfer and performed passively in 82% of centres with a target rectal temperature of 33-34 °C. Most units ventilated infants with perinatal asphyxial encephalopathy if clinically indicated and 73% of responders gave analgesia routinely to cooled infants. Neuromonitoring included continuous amplitude integrated EEG (aEEG) and EEG. Neuroimaging included cranial ultrasound (cUS), magnetic resonance imaging (MRI) and computed tomography (CT). Sixty-seven percent of units treating infants with perinatal asphyxial encephalopathy performed MRI routinely. All heads of departments questioned indicated that a "Swiss National Asphyxia and Cooling Registry" is needed. CONCLUSIONS: In Switzerland, access to therapeutic hypothermia is widespread and Swiss neonatologists believe that therapeutic hypothermia for perinatal asphyxia is effective. National cooling protocols are needed for the management of infants with perinatal asphyxial encephalopathy in order to ensure safe cooling, appropriate monitoring, imaging and follow-up assessment. A national registry is needed to collect data on diagnosis, treatment, adverse events and outcome. |
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Authors:
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C F Hagmann; B Brotschi; V Bernet; B Latal; T M Berger; N J Robertson |
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Publication Detail:
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Type: Journal Article Date: 2011-02-16 |
Journal Detail:
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Title: Swiss medical weekly Volume: 141 ISSN: 1424-3997 ISO Abbreviation: Swiss Med Wkly Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100970884 Medline TA: Swiss Med Wkly Country: Switzerland |
Other Details:
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Languages: eng Pagination: w13145 Citation Subset: IM |
Affiliation:
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Klinik für Neonatologie, Frauenklinikstrasse 10, 8091 Zürich, CH. cornelia.hagmann@usz.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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