Document Detail


Hypothermia modulates induction of hsp70 and c-jun mRNA in the rat brain after subarachnoid hemorrhage.
MedLine Citation:
PMID:  10757329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated expression of hsp70 and c-jun mRNA with in situ hybridization for evaluating hypothermia effect on the brain exposed to subarachnoid hemorrhage (SAH). SAH was induced in Wistar rats with endovascular perforation. Animals were divided arbitrarily into normothermic and hypothermic groups, and they were sacrificed at 3 h or 12 h after SAH. The SAH induced hsp70 and c-jun mRNAs in the cerebral cortex, hippocampus, thalamus, hypothalamus, and caudoputamen. Mild hypothermia depressed hsp70 mRNA expression in the cortex, thalamus, and hippocampus. The c-jun mRNA expression was reduced by hypothermia in the cortex, thalamus, and CA1 of the hippocampus. Based on these findings, we speculate that hypothermia protects the brain exposed to SAH by reducing this stress response. Although it is yet difficult to employ hypothermia in the clinical settings, this study suggests its utility to those patients sustaining severe subarachnoid hemorrhage.
Authors:
Y Kawamura; K Yamada; A Masago; H Katano; T Matsumoto; M Mase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  17     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Nagoya City University Medical School, Nagoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology*,  physiopathology*
Disease Models, Animal
Gene Expression Regulation
HSP70 Heat-Shock Proteins / metabolism*
Hypothermia, Induced*
Male
Proto-Oncogene Proteins c-jun / metabolism*
RNA, Messenger / metabolism
Rats
Rats, Wistar
Subarachnoid Hemorrhage / metabolism,  pathology*,  physiopathology*
Chemical
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger

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