| Hypothermia: its possible role in cardiac surgery. | |
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MedLine Citation:
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PMID: 2658888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current safety of operations on the heart requiring cardiopulmonary bypass occurred because of a series of step-by-step laboratory and clinical investigations that were compromises between the time needed for heart repair and the brain's requirement for oxygen. The first step, so clearly shown in a paper by Bigelow and associates in 1950, was the reduction of the brain's need for oxygen by surface cooling to 28 degrees to 32 degrees C, limited to this level by cardiac and pulmonary failure at levels lower than this. The six to eight minutes of circulatory arrest permitted time for repair of simple defects. This method was rapidly adopted by many surgeons. As low-flow pump oxygenators became available, blood cooling to 10 degrees to 20 degrees C was introduced. This increased the periods of circulatory arrest to 30 to 60 minutes, and also made still longer periods of bypass with the pump oxygenator possible. Hypothermia to reduce oxygen and metabolic requirements is still an important adjunct to bypass, even with the currently used efficient pump oxygenators. It remains the most important component of myocardial preservation, and has made possible the delay needed for transportation between the harvesting and the transplantation of organs. |
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Authors:
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W C Sealy |
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Publication Detail:
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Type: Biography; Historical Article; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 47 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-06-27 Completed Date: 1989-06-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 788-91 Citation Subset: AIM; IM; Q |
Affiliation:
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Sanger Clinic, Charlotte, North Carolina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures
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history* History, 20th Century Humans Hypothermia, Induced / history* |
| Personal Name Subject | |
Personal Name Subject:
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W G Bigelow |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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