| Hypothermia inhibits the alveolar epithelial injury caused by hyposmotic albumin solution during preservation of the resected human lung. | |
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MedLine Citation:
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PMID: 9306546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to determine whether hypothermia inhibited alveolar epithelial injury in the resected human lung during preservation. Hyposmotic albumin solution, 248 mOsm/kg, was instilled into the alveolar spaces of resected human lungs which were inflated with an airway pressure of 7 cmH2O and stored at either 37 degrees C or 8 degrees C for 4 h. Alveolar fluid was aspirated and the influx of lactate dehydrogenase (LDH) and globulin into the alveolar spaces, as markers of alveolar epithelial injury, was measured. Ion transport and fluid clearance across the alveolar epithelium were calculated by the changes in electrolyte and albumin concentrations in the alveolar fluid, respectively. While the LDH levels and globulin concentrations increased significantly in the hyposmotic experiments at 37 degrees C, hypothermia inhibited these increases. Alveolar fluid clearance at 37 degrees C increased to 20% in the hyposmotic experiments compared with 12% in the control isosmotic experiments; however, sodium and chloride transport in the hyposmotic experiments was not significantly different from that in the isosmotic experiments. Thus, we conclude that hypothermia at 8 degrees C inhibits alveolar epithelial injury caused by the hyposmotic solution in resected human lungs. Moreover, alveolar ion and fluid clearance mechanisms were preserved across the injured alveolar epithelial cells. |
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Authors:
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T Sakuma; T Nishimura; K Usude; M Handa; G Okaniwa; S Suzuki; S Fujimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery today Volume: 27 ISSN: 0941-1291 ISO Abbreviation: Surg. Today Publication Date: 1997 |
Date Detail:
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Created Date: 1997-10-22 Completed Date: 1997-10-22 Revised Date: 2006-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: JAPAN |
Other Details:
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Languages: eng Pagination: 527-33 Citation Subset: IM |
Affiliation:
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Department of Surgery, Sendai Kosei Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epithelium
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pathology Humans Hypothermia, Induced* Ion Transport L-Lactate Dehydrogenase / analysis Lung* / metabolism, pathology Lung Transplantation Organ Preservation* Organ Preservation Solutions* Osmolar Concentration Pulmonary Alveoli / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Organ Preservation Solutions; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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