| Hypothermia impairs but hyperthermia does not promote inert gas elimination in the rat. | |
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MedLine Citation:
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PMID: 3727179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The volume of nitrogen eliminated (VN2) and washout rate constant (k) during a 2-h period of O2 breathing in the rat was altered in response to changes in body temperature. VN2 and cardiac output (Q) were determined simultaneously on 3 groups of unanesthetized but restrained male rats at 3 different body temperatures: normothermic (36 degrees C), hyperthermic (39 degrees C), and hypothermic (33 degrees C). Under normothermic conditions, the rats eliminated 12.8 ml N2/kg in 2 h of O2 breathing while Q, determined by a thermodilution technique, was 430 ml X min-1 X kg-1. A significant reduction in VN2 (33%) and k (44%) was seen during hypothermic exposures in which rectal temperature dropped 3 degrees C and Q decreased to 395 ml X min-1 X kg-1. During hyperthermic exposures, VN2, 11.7 ml N2/kg, and k decreased while Q increased to 468 ml X min-1 X kg-1, however, these changes were not significant when compared to the normothermic conditions. The overall relationship between VN2 and Q is described by: VN2 = 4.44 + 0.019 Q (r = 0.536, P less than 0.01). Under conditions of altered body temperature, Q accounts for only 29% of the VN2 response. Characteristic changes in regional blood flow, such as a decreased adipose tissue blood flow, may account for the observed reduction in VN2 and k during hypo- and hyperthermic conditions. The results of this study indicate that hypothermia prolongs the duration required for desaturation of nitrogen. |
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Authors:
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G W Mack; Y C Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Undersea biomedical research Volume: 13 ISSN: 0093-5387 ISO Abbreviation: Undersea Biomed Res Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-08-21 Completed Date: 1986-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421514 Medline TA: Undersea Biomed Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 133-45 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Body Temperature* Cardiac Output* Heart Rate Kinetics Male Nitrogen / physiology* Oxygen Consumption Rats Rats, Inbred Strains Respiration* Temperature |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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