| Hypothermia following intraventricular injection of hemicholinium-3 in rats. | |
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MedLine Citation:
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PMID: 5768128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In unanaesthetized rats, a dose of 50 mug of hemicholinium-3 injected into the cerebral ventricles produced a prolonged hypothermia which was unaffected by the simultaneous administration of choline. This suggests that it was not due to inhibition of acetylcholine synthesis.2. An intraperitoneal injection of 50 mug of hemicholinium-3 also produced hypothermia which, however, was blocked by choline which suggests that it is due to inhibition of acetylcholine synthesis.3. Hyoscine and hexamethonium did not block the hypothermia produced by intraventricular hemicholinium-3, but some antagonism was obtained with phentolamine, imipramine and amphetamine.4. When hemicholinium-3 was administered intraventricularly to rats pretreated with desmethylimipramine, a lethal hyperthermia developed.5. It is concluded that no central cholinergic mechanism is involved in the hypothermia of the rat resulting from an intraventricular injection of hemicholinium-3. |
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Authors:
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P Slater |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 36 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1969 May |
Date Detail:
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Created Date: 1969-06-26 Completed Date: 1969-06-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 46-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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biosynthesis Amphetamine / pharmacology Animals Biphenyl Compounds / pharmacology* Body Temperature / drug effects* Cerebral Ventricles* Choline / pharmacology Desipramine / pharmacology Hexamethonium Compounds / pharmacology Imipramine / pharmacology Male Parasympatholytics / pharmacology* Phentolamine / pharmacology Rats Scopolamine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 0/Hexamethonium Compounds; 0/Parasympatholytics; 300-62-9/Amphetamine; 50-47-5/Desipramine; 50-49-7/Imipramine; 50-60-2/Phentolamine; 51-34-3/Scopolamine; 51-84-3/Acetylcholine; 62-49-7/Choline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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