| Hypothermia following acute carbon-monoxide poisoning increases mortality. | |
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MedLine Citation:
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PMID: 2378003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of body temperature during recovery from acute severe carbon monoxide (CO) poisoning on morbidity and mortality was investigated using an unanesthetized animal model. Levine prepared female rats were exposed to 2700 ppm CO for 90 min, displaying the usual hypothermia, hypotension and bradycardia. Body temperature in survivors was either maintained at the terminal CO exposure value for 4 h ('cooled'), rapidly raised to the pre-CO exposure value for 4 h ('heated') or allowed to return to normal naturally ('unheated'). Following this period of recovery, the 'heated' rats sustained the lowest mortality rate (22%), the 'unheated' rats a greater mortality rate (44%), and the 'cooled' rats the highest mortality rate (50%). Inclusive of the surviving rats, there were no significant differences in neurologic deficit between the three groups, after 4, 24 or 48 h of recovery. Aside from a significant delay in recovery of blood pressure in the 'heated' rats relative to the other two treatment groups post-CO, there were no differences in blood pressure, heart rate or plasma glucose. The results suggest that rapid return to euthermia improves survival following acute severe CO poisoning, contrasting with an earlier study showing the detrimental effect of euthermia during CO poisoning. |
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Authors:
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B B Sutariya; D G Penney; B G Nallamothu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 52 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-09-04 Completed Date: 1990-09-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 201-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Blood Pressure / drug effects Body Temperature Carbon Monoxide / toxicity Carbon Monoxide Poisoning / complications*, mortality Female Heart Rate / drug effects Hyperthermia, Induced Hypothermia / etiology*, mortality Hypothermia, Induced Models, Biological Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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