Document Detail

Hypothermia down-regulates the LPS-induced norepinephrine (NE) release in ischaemic human heart cells.
MedLine Citation:
PMID:  21963948     Owner:  NLM     Status:  Publisher    
Hypothermia has been widely acknowledged as the fundamental component of myocardial protection during cardiac operations. In this work, we studied in human atrial tissue the effect of the common hypothermic protection used in cardiac surgery, and we assessed this effect by comparing catecholamine release among normoxic, ischaemic, and inflammatory conditions. Our results provide the first evidence that lipopolysaccharide treatment results in an extremely dramatic and significant increase in the resting norepinephrine release under ischaemic conditions that can be normalised by hypothermia. These findings demonstrate that inflammatory conditions increase the temperature sensitivity of the norepinephrine transporter in human cardiac tissue. When the possible pharmacological interventions are taken into consideration, the results presented here provide new insight into the protection against ischaemia/reperfusion injury during cardiac surgery.
Miklós Szelényi; Zoltán László; Zoltán Szabó; Zsanett Kromplák; Erika Tischler; Marcell Lakatos; László Székely
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-24
Journal Detail:
Title:  Brain research bulletin     Volume:  -     ISSN:  1873-2747     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
St. Margit Hospital, Bécsi út 132, H-1032 Budapest, Hungary.
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