Document Detail

Hypothermia for cardiac arrest.
MedLine Citation:
PMID:  17074288     Owner:  NLM     Status:  MEDLINE    
Therapeutic hypothermia for cardiac arrest survivors has emerged as a highly effective means of improving neurologic outcome. There are a number of purported mechanisms by which it is felt to be effective, but the exact mechanism is unknown. This article reviews the biochemical mechanisms of injury occurring in cardiac arrest, as well as the avenues that hypothermia takes to combat this injury. It also reviews the animal model data in support of this, as well as the newer animal studies that may help to improve the field. Several human studies of hypothermia in cardiac arrest have been performed, and this article reviews these for their methods and shortcomings. Our currently recommended guidelines for performing therapeutic hypothermia are presented. With therapeutic hypothermia comes potential risks to the patient, primarily affecting cardiac, metabolic, and hematologic systems, and these risks and their management are discussed. Multiple methods of cooling exist, including selective cranial as well as systemic cooling by internal or external approaches. Finally, the article discusses the current research in the field of hypothermia for cardiac arrest and implications for future practice.
David M Greer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  6     ISSN:  1528-4042     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-24     Citation Subset:  IM    
Massachusetts General Hospital, ACC 835, 55 Fruit Street, Boston, MA 02114, USA.
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MeSH Terms
Heart Arrest / physiopathology*,  therapy*
Hypothermia, Induced*
Practice Guidelines as Topic
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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