Document Detail

Hypothermia attenuates delayed cortical cell death and ROS generation following CO inhalation.
MedLine Citation:
PMID:  14581162     Owner:  NLM     Status:  MEDLINE    
Carbon monoxide (CO) is the most popular cause of poisoning. The bilateral basal ganglia lesion characterizes the delayed neuronal cell death (DCD). We demonstrated there were both apoptosis and necrosis in the cortex, basal ganglia and hippocampus in a case of human CO accident. To elucidate the mechanism of DCD after CO inhalation, histological studies on the rat brain were conducted. Rats were ventilated with nitrous oxide (sham group), 10% O(2) (hypoxia group) or 1005 ppm CO (CO group) for 90 min, while the pericranial temperature was controlled at either 32, 37, or 39 degrees C during CO inhalation. After reoxygenation for 30 min, the rats were allowed to recover for 48 h. The ratio of eosinophilic and HNE-positive neurons in the cortex were higher in the CO group than in the hypoxia group at 37 degrees C, while the PaO(2) was much lower in the hypoxia than in the CO group. The damage was alleviated in the hypothermia (32 degrees C) as compared with normothermia, while the hyperthermia (39 degrees C) did not significantly increased it. CO inhalation injures neuron by reactive oxygen species (ROS), independent of hypoxia, as can be concluded from the histological comparison of DCD with HNE immunoreactivity.
Koichi Uemura; Sumihisa Hoshino; Koji Uchida; Ryosuke Tsuruta; Tsuyoshi Maekawa; Ken-ichi Yoshida
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  145     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2003-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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MeSH Terms
Aldehydes / metabolism
Apoptosis / drug effects
Blood Pressure / drug effects
Carbon Monoxide / metabolism*,  toxicity
Carbon Monoxide Poisoning / metabolism,  pathology*
Cerebral Cortex / metabolism,  pathology*
Heart Rate / drug effects
Hypothermia, Induced*
In Situ Nick-End Labeling
Neurons / metabolism,  pathology*
Random Allocation
Rats, Wistar
Reactive Oxygen Species / metabolism*
Reg. No./Substance:
0/Aldehydes; 0/Reactive Oxygen Species; 29343-52-0/4-hydroxy-2-nonenal; 630-08-0/Carbon Monoxide

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