Document Detail

Hypothermia as cerebroprotective measure. Experimental hypoxic exposure of brain slices and clinical application in critically reduced cerebral perfusion pressure.
MedLine Citation:
PMID:  9584927     Owner:  NLM     Status:  MEDLINE    
An in vitro human neocortical and rodent hippocampus brain slice technique was used under repeated hypoxia to investigate the cerebroprotective effect of hypothermia. As a hallmark of the neuronal hypoxic reaction anoxic terminal negativity (ATN) was registered to test whether hypothermia delays the onset of ATN. The experiments clearly confirm an assumed protective effect of hypothermia in vitro and in vivo and give for the first time evidence of the lack of the protective effect of hypothermia once hypoxia has occurred under normothermic conditions, probably by a critical depletion of cellular ATP-stores. In patients with severe traumatic brain injury and critically low cerebral perfusion pressure mild hypothermia is able to improve clinical outcome.
H Wassmann; C Greiner; S Hülsmann; D Moskopp; E J Speckmann; J Meyer; H Van Aken
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  20 Suppl 1     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-15     Completed Date:  1998-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S61-5     Citation Subset:  IM    
Klinik and Poliklinik für Neurochirurgie, Westfälische Wilhelms-Universität, Münster, Germany.
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MeSH Terms
Anesthetics, Intravenous / administration & dosage
Brain Injuries / therapy*
Cerebral Cortex / physiopathology
Evoked Potentials / physiology
Hippocampus / physiopathology
Hypothermia, Induced*
Hypoxia, Brain / therapy*
Intracranial Pressure
Methohexital / administration & dosage
Organ Culture Techniques
Perfusion / methods
Reg. No./Substance:
0/Anesthetics, Intravenous; 18652-93-2/Methohexital

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