| Hypothermia as cerebroprotective measure. Experimental hypoxic exposure of brain slices and clinical application in critically reduced cerebral perfusion pressure. | |
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MedLine Citation:
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PMID: 9584927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An in vitro human neocortical and rodent hippocampus brain slice technique was used under repeated hypoxia to investigate the cerebroprotective effect of hypothermia. As a hallmark of the neuronal hypoxic reaction anoxic terminal negativity (ATN) was registered to test whether hypothermia delays the onset of ATN. The experiments clearly confirm an assumed protective effect of hypothermia in vitro and in vivo and give for the first time evidence of the lack of the protective effect of hypothermia once hypoxia has occurred under normothermic conditions, probably by a critical depletion of cellular ATP-stores. In patients with severe traumatic brain injury and critically low cerebral perfusion pressure mild hypothermia is able to improve clinical outcome. |
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Authors:
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H Wassmann; C Greiner; S Hülsmann; D Moskopp; E J Speckmann; J Meyer; H Van Aken |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurological research Volume: 20 Suppl 1 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-15 Completed Date: 1998-06-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S61-5 Citation Subset: IM |
Affiliation:
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Klinik and Poliklinik für Neurochirurgie, Westfälische Wilhelms-Universität, Münster, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Intravenous / administration & dosage Animals Brain Injuries / therapy* Cerebral Cortex / physiopathology Evoked Potentials / physiology Female Hippocampus / physiopathology Humans Hypothermia, Induced* Hypoxia, Brain / therapy* Intracranial Pressure Methohexital / administration & dosage Organ Culture Techniques Perfusion / methods Pressure Rodentia |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 18652-93-2/Methohexital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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