| Hypothermia after cardiac arrest. | |
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MedLine Citation:
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PMID: 19732608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mild therapeutic hypothermia (32 degrees C-34 degrees C) is the only therapy that improved neurological outcome after cardiac arrest in a randomized, controlled trial. Induced hypothermia after successful resuscitation leads to one additional patient with intact neurological outcome for every 6 patients treated. It protects the brain after ischemia by reduction of brain metabolism, attenuation of reactive oxygen species formation, inhibition of excitatory amino acid release, attenuation of the immune response during reperfusion, and inhibition of apoptosis. Potential side effects such as infections have to be kept in mind and treated accordingly. Mild hypothermia is a safe and effective therapy after cardiac arrest, even in hemodynamically compromised patients and in patients undergoing percutaneous coronary intervention. Its use is recommended by the American Heart Association and the International Liaison Committee on Resuscitation for unconscious adult patients with spontaneous circulation after out-of-hospital ventricular fibrillation cardiac arrest. Further research is needed to maximize its potential benefits. |
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Authors:
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Andreas Janata; Michael Holzer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in cardiovascular diseases Volume: 52 ISSN: 1532-8643 ISO Abbreviation: - Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-09-07 Completed Date: 2009-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376442 Medline TA: Prog Cardiovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 168-79 Citation Subset: AIM; IM |
Affiliation:
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andreas.janata@meduniwien.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Blood Coagulation Brain Ischemia / etiology, prevention & control*, therapy Cardiopulmonary Resuscitation Heart Arrest / complications, therapy* Hemodynamics Humans Hypothermia / physiopathology Hypothermia, Induced* / adverse effects, methods Hypoxia-Ischemia, Brain / prevention & control Shivering / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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