Document Detail


Hypothermia for acute ischaemic stroke.
MedLine Citation:
PMID:  23415567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischaemic stroke is one of the leading causes of death and disability worldwide, and intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia has been shown to improve neurological outcomes after global ischaemia-hypoxia in comatose patients who have had cardiac arrest, and is one of the most extensively studied and powerful therapeutic strategies in acute ischaemic stroke. The protective mechanisms of therapeutic hypothermia affect the ischaemic cascade across several parallel pathways and, when coupled with reperfusion strategies, might yield synergistic benefits for patients who have had a stroke. Technological advances have allowed hypothermia to be induced rapidly, and the treatment has been used safely in acute stroke patients. Conclusive efficacy trials assessing therapeutic hypothermia combined with reperfusion therapies in acute ischaemic stroke are ongoing.
Authors:
Tzu-Ching Wu; James C Grotta
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  12     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-04-18     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / drug therapy,  therapy*
Combined Modality Therapy / adverse effects,  instrumentation,  methods*
Fibrinolytic Agents / therapeutic use
Humans
Hypothermia*
Stroke / drug therapy,  therapy*
Tissue Plasminogen Activator / therapeutic use
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator

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