Document Detail

Hypothermia for acute ischaemic stroke.
MedLine Citation:
PMID:  23415567     Owner:  NLM     Status:  MEDLINE    
Ischaemic stroke is one of the leading causes of death and disability worldwide, and intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia has been shown to improve neurological outcomes after global ischaemia-hypoxia in comatose patients who have had cardiac arrest, and is one of the most extensively studied and powerful therapeutic strategies in acute ischaemic stroke. The protective mechanisms of therapeutic hypothermia affect the ischaemic cascade across several parallel pathways and, when coupled with reperfusion strategies, might yield synergistic benefits for patients who have had a stroke. Technological advances have allowed hypothermia to be induced rapidly, and the treatment has been used safely in acute stroke patients. Conclusive efficacy trials assessing therapeutic hypothermia combined with reperfusion therapies in acute ischaemic stroke are ongoing.
Tzu-Ching Wu; James C Grotta
Related Documents :
7118517 - Effects of low osmolality contrast materials on coronary hemodynamics, myocardial funct...
8970577 - The cardiac endothelium: cardioactive mediators.
3941367 - Separate effects of ischemia, hypoxia, and contractility on thallium-201 kinetics in ra...
14627617 - Regulation of cardiac excitation-contraction coupling: a cellular update.
20653807 - Mitral isthmus block in a case of persistent left superior vena cava.
8634857 - Beneficial effects of hypertonic mannitol in acute ischemia--reperfusion injuries in hu...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  12     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-04-18     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Ischemia / drug therapy,  therapy*
Combined Modality Therapy / adverse effects,  instrumentation,  methods*
Fibrinolytic Agents / therapeutic use
Stroke / drug therapy,  therapy*
Tissue Plasminogen Activator / therapeutic use
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An autoinhibited state in the structure of Thermotoga maritima NusG.
Next Document:  Somnambulism: clinical aspects and pathophysiological hypotheses.