Document Detail


Hypothermia and Early Neonatal Mortality in Preterm Infants.
MedLine Citation:
PMID:  24210925     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate intervention practices associated with hypothermia at both 5 minutes after birth and at neonatal intensive care unit (NICU) admission and to determine whether hypothermia at NICU admission is associated with early neonatal death in preterm infants.
STUDY DESIGN: This prospective cohort included 1764 inborn neonates of 22-33 weeks without malformations admitted to 9 university NICUs from August 2010 through April 2012. All centers followed neonatal International Liaison Committee on Resuscitation recommendations for the stabilization and resuscitation in the delivery room (DR). Variables associated with hypothermia (axillary temperature <36.0°C) 5 minutes after birth and at NICU admission, as well as those associated with early death, were analyzed by logistic regression.
RESULTS: Hypothermia 5 minutes after birth and at NICU admission was noted in 44% and 51%, respectively, with 6% of early neonatal deaths. Adjusted for confounding variables, practices associated with hypothermia at 5 minutes after birth were DR temperature <25°C (OR 2.13, 95% CI 1.67-2.28), maternal temperature at delivery <36.0°C (OR 1.93, 95% CI 1.49-2.51), and use of plastic bag/wrap (OR 0.53, 95% CI 0.40-0.70). The variables associated with hypothermia at NICU admission were DR temperature <25°C (OR 1.44, 95% CI 1.10-1.88), respiratory support with cold air in the DR (OR 1.40, 95% CI 1.03-1.88) and during transport to NICU (OR 1.51, 95% CI 1.08-2.13), and cap use (OR 0.55, 95% CI 0.39-0.78). Hypothermia at NICU admission increased the chance of early neonatal death by 1.64-fold (95% CI 1.03-2.61).
CONCLUSION: Simple interventions, such as maintaining DR temperature >25°C, reducing maternal hypothermia prior to delivery, providing plastic bags/wraps and caps for the newly born infants, and using warm resuscitation gases, may decrease hypothermia at NICU admission and improve early neonatal survival.
Authors:
Maria Fernanda Branco de Almeida; Ruth Guinsburg; Guilherme Assis Sancho; Izilda Rodrigues Machado Rosa; Zeni Carvalho Lamy; Francisco Eulógio Martinez; Regina Paula Guimarães Vieira Cavalcante da Silva; Lígia Silvana Lopes Ferrari; Ligia Maria Suppo de Souza Rugolo; Vânia Olivetti Steffen Abdallah; Rita de Cássia Silveira;
Related Documents :
23839905 - Purpura fulminans after therapeutic hypothermia in an asphyxiated neonate with streptoc...
21948615 - Ntp-cerhr expert panel report on the developmental toxicity of soy infant formula.
21770835 - Effect of low versus high early parenteral nutrition on plasma amino acid profiles in v...
22990515 - Single embryo transfer reduces the risk of perinatal mortality, a population study.
7437105 - Biometric and dynamic ultrasound assessment of small-for-dates infants: report of 260 c...
22575245 - Cerebrospinal fluid reference ranges in term and preterm infants in the neonatal intens...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-6
Journal Detail:
Title:  The Journal of pediatrics     Volume:  -     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
Affiliation:
Division of Neonatal Medicine, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Variation in feeding practices following the Norwood procedure.
Next Document:  Brain Magnetic Resonance Imaging in Infants with Surgical Necrotizing Enterocolitis or Spontaneous I...