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Hypothermia for Acute Spinal Cord Injury - A Review.
MedLine Citation:
PMID:  23298671     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Spinal cord injury (SCI) is a catastrophic neurological event with no proven treatments that protect against its consequences. Potential benefits of hypothermia in preventing/limiting central nervous system (CNS) injury are now well known. There has been an interest in its potential use after SCI. This article reviews the current experimental and clinical evidence on the use of therapeutic hypothermia in patients with SCI. METHOD: Review of literature. RESULTS: There are various mechanisms by which hypothermia is known to protect the CNS. Modest hypothermia (32-34 °C) can deliver the potential benefits of hypothermia without incurring the complications associated with deep hypothermia. Several recent experimental studies have repeatedly shown that the use of hypothermia provides the benefit of neuroprotection after SCI. While older clinical studies were often focused on local cooling strategies and demonstrated mixed results, more recent data from systemic hypothermia use demonstrates its safety and its benefits. Endovascular cooling is a safe and reliable method of inducing hypothermia. CONCLUSION: There is robust experimental and some clinical evidence that hypothermia is beneficial in acute SCI. Larger, multicenter trials should be initiated to further study the usefulness of systemic hypothermia in SCI.
Authors:
Faiz Ahmad; Michael Y Wang; Allan D Levi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-5
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  World Neurosurg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurological Surgery, University of Miami MILLER School of Medicine, Miami, Florida, USA.
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