Document Detail

Hypothalamus and pituitary volume in schizophrenia: a structural MRI study.
MedLine Citation:
PMID:  21733239     Owner:  NLM     Status:  MEDLINE    
Volumetric differences of the hypothalamus and/or the pituitary gland tend to support involvement of the HPA axis in psychotic disorders. These structures were manually outlined in 154 schizophrenia patients and 156 matched healthy comparison subjects by MRI brain images. Linear regression analyses were performed to investigate differences in volume between groups. Moreover, the effects of illness duration and type of medication were investigated. No significant differences were found between patients and healthy controls in volumes of the hypothalamus and pituitary gland. In addition, there were no differences in volumes between patients with short and long illness duration. There was a trend towards patients receiving typical antipsychotic medication at the time of scanning having larger pituitary volumes than patients receiving atypical medication. These findings indicate that volume decreases in brain structures important for the normal functioning of the HPA axis are not present, either in recent-onset or chronically ill patients.
Anne Klomp; P Cédric M P Koolschijn; Hilleke E Hulshoff Pol; René S Kahn; Neeltje E M Van Haren
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Publication Detail:
Type:  Journal Article     Date:  2011-05-20
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  15     ISSN:  1469-5111     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-09-27     Revised Date:  2012-10-16    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-8     Citation Subset:  IM    
Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Case-Control Studies
Hypothalamus / pathology*
Magnetic Resonance Imaging*
Middle Aged
Organ Size
Pituitary Gland / pathology*
Schizophrenia / pathology*
Young Adult

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