| Hypothalamo-pituitary function and dopamine dependence in untreated parkinsonian patients. | |
| | |
MedLine Citation:
|
PMID: 1903236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Altered prolactin and thyrotropin responses to the TRH test in parkinsonian patients are held to indicate an impairment of the tubero-infundibular dopaminergic axis (TIDA). We correlated the plasmatic prolactin (PRL), thyrotropin (TSH) and somatotropin (GH) responses to TRH and bromocriptine + TRH of 12 parkinsonian patients, who had never received anti-parkinsonian drugs, with the severity, the duration, the age of onset and the dopamine-dependence of the motor symptomatology as indicated by the therapeutic response to a six-month oral treatment with bromocriptine. Patients with basal motor impairment over 9 on the Webster Rating Scale (WRS), those with duration of the disease over 24 months and those with onset earlier than 55 years of age showed lower PRL responses than the respectively matched subgroups. Patients showing a therapeutic motor improvement over 50% on the WRS (dopamine-dependent or "responder") showed lower PRL and TSH and higher GH responses than the non-responders. These findings suggest that the TIDA impairment described in Parkinson's disease develops along with the progressive course of the extrapyramidal involvement and is strictly correlated with the dopamine-dependence of the motor impairment. |
| | |
Authors:
|
G Cusimano; C Capriani; V Bonifati; G Meco |
Related Documents
:
|
8460856 - Hypopituitarism after tuberculous meningitis in childhood. 11446676 - Three patients with isolated adrenocorticotropin deficiency presenting with neuroleptic... 18183856 - Nodular pulmonary histoplasmosis in cushing's disease: a case report and literature rev... 68286 - Impact of new diagnostic methods on the differential diagnosis and treatment of seconda... 18217506 - Benign paroxysmal positional vertigo in mountain bikers. 11284086 - Patients with persistent apc-resistance without factor v leiden mutation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta neurologica Scandinavica Volume: 83 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1991-06-20 Completed Date: 1991-06-20 Revised Date: 2006-08-16 |
Medline Journal Info:
|
Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 145-50 Citation Subset: IM |
Affiliation:
|
Department of Neurological Sciences, University La Sapienza, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Bromocriptine / administration & dosage Dopamine / physiology* Female Growth Hormone / blood Humans Hypothalamo-Hypophyseal System / drug effects, physiopathology* Male Middle Aged Neurologic Examination Parkinson Disease / drug therapy, physiopathology* Prolactin / blood Thyrotropin / blood Thyrotropin-Releasing Hormone / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
24305-27-9/Thyrotropin-Releasing Hormone; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Subtle primary hypothyroidism in patients treated for acute lymphoblastic leukemia.
Next Document: Refractory depression: the addition of lithium to fluoxetine or desipramine.