| Hypothalamic thermosensitivity in capsaicin-desensitized rats. | |
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MedLine Citation:
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PMID: 4020699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In rats, we tested the hypothesis that capsaicin desensitization reduces hypothalamic warm thermosensitivity. We locally heated and cooled the hypothalamus using water-perfused thermodes while observing thermoregulatory variables. In untreated rats, a small dose of capsaicin had profound effects on thermoregulation. However, desensitizing rats to capsaicin had no effect on hypothalamic thermosensitivity for metabolic rate or changes in body temperature due to displacements of hypothalamic temperature. Contrary to current opinion, we conclude that capsaicin desensitization does not alter hypothalamic thermosensitivity to warm or cold. |
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Authors:
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M Cormarèche-Leydier; S G Shimada; J T Stitt |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of physiology Volume: 363 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-09-11 Completed Date: 1985-09-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 227-36 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Body Temperature Regulation / drug effects* Capsaicin / pharmacology* Cold Temperature Hot Temperature Hypothalamus / physiology* Male Metabolism Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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NS-11487/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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