Document Detail

Hypothalamic regulation of energy homeostasis.
MedLine Citation:
PMID:  12468411     Owner:  NLM     Status:  MEDLINE    
The co-ordinated regulation of food intake and energy expenditure takes place in the hypothalamic regions of the brain. Current understanding of the systems involved in this regulation suggests that, in the hypothalamus, there are two major groups of neuropeptides involved in orexigenic and anorexic processes. The orexigenic neuropeptides are neuropeptide Y (NPY) and agouti-related peptide (AgRP) and the anorexic neuropeptides are alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine and amphetamine-related transcript (CART). Theneurons expressing these neuropeptides interact with each other and with signals from the periphery (such as leptin, insulin, ghrelin and glucocorticoids) to regulate feeding behaviour, energy expenditure and various endocrine axes. Although direct evidence is limited, there are examples of genetic obesity in humans which suggest that the balance between orexigenic and anorexic pathways in the hypothalamus is also pivotally important in the maintenance of energy homeostasis in humans.
Amanda Sainsbury; Gregory J Cooney; Herbert Herzog
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  16     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-06     Completed Date:  2003-06-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  623-37     Citation Subset:  IM    
Neurobiology Research Program, The Garvan Institute of Medical Research, Sydney, Australia.
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MeSH Terms
Agouti-Related Protein
Energy Metabolism*
Hypothalamus / physiology*
Intercellular Signaling Peptides and Proteins
Mice, Knockout
Nerve Tissue Proteins / physiology
Neurons / physiology
Neuropeptide Y / physiology
Obesity / genetics
Proteins / physiology
alpha-MSH / physiology
Reg. No./Substance:
0/Agouti-Related Protein; 0/Intercellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/Proteins; 0/cocaine- and amphetamine-regulated transcript protein; 581-05-5/alpha-MSH

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