| Hypothalamic--pituitary--adrenal axis and monoamine transmitter activity in depression: a pilot study of central and peripheral effects of electroconvulsive therapy. | |
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MedLine Citation:
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PMID: 1707686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central and peripheral measures of hypothalamic--pituitary--adrenal (HPA) axis and monoamine neurotransmitter activity were assessed in 8 depressed patients during a medication-free period and again after completion of a course of electroconvulsive therapy (ECT). Seven patients responded fully to ECT. At baseline there was corresponding activation of the HPA and noradrenergic systems, with apparent elevation in cerebrospinal fluid (CSF) concentrations of corticotropin-releasing hormone (CRH) in some patients. Neither CRH nor adrenocorticotropin (ACTH) in CSF changed significantly after ECT, with a mean 10% decline in CSF CRH. Urinary free cortisol (UFC) excretion was high both before and after treatment. Although peripheral noradrenergic hyperreactivity at baseline appeared to normalize with ECT, CSF concentrations of the principal norepinephrine metabolite, 3-methoxy-4-hydroxyphenyl-glycol (MHPG) were unaffected and remained correlated with CSF CRH. In contrast, there were increases in the CSF levels of the main metabolite of serotonin in half the patients. |
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Authors:
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M V Rudorfer; E D Risby; O T Osman; P W Gold; W Z Potter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological psychiatry Volume: 29 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-05-23 Completed Date: 1991-05-23 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-64 Citation Subset: IM |
Affiliation:
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Section on Clinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Catecholamines / metabolism Corticotropin-Releasing Hormone / metabolism Depressive Disorder / physiopathology*, psychology, therapy Electroconvulsive Therapy* Female Humans Hydrocortisone / metabolism Hydroxyindoleacetic Acid / metabolism Hypothalamo-Hypophyseal System / physiopathology* Male Methoxyhydroxyphenylglycol / metabolism Middle Aged Neurotransmitter Agents / metabolism* Pituitary-Adrenal System / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Neurotransmitter Agents; 50-23-7/Hydrocortisone; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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