Document Detail

Hypothalamic--pituitary--adrenal axis and monoamine transmitter activity in depression: a pilot study of central and peripheral effects of electroconvulsive therapy.
MedLine Citation:
PMID:  1707686     Owner:  NLM     Status:  MEDLINE    
Central and peripheral measures of hypothalamic--pituitary--adrenal (HPA) axis and monoamine neurotransmitter activity were assessed in 8 depressed patients during a medication-free period and again after completion of a course of electroconvulsive therapy (ECT). Seven patients responded fully to ECT. At baseline there was corresponding activation of the HPA and noradrenergic systems, with apparent elevation in cerebrospinal fluid (CSF) concentrations of corticotropin-releasing hormone (CRH) in some patients. Neither CRH nor adrenocorticotropin (ACTH) in CSF changed significantly after ECT, with a mean 10% decline in CSF CRH. Urinary free cortisol (UFC) excretion was high both before and after treatment. Although peripheral noradrenergic hyperreactivity at baseline appeared to normalize with ECT, CSF concentrations of the principal norepinephrine metabolite, 3-methoxy-4-hydroxyphenyl-glycol (MHPG) were unaffected and remained correlated with CSF CRH. In contrast, there were increases in the CSF levels of the main metabolite of serotonin in half the patients.
M V Rudorfer; E D Risby; O T Osman; P W Gold; W Z Potter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  29     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-23     Completed Date:  1991-05-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-64     Citation Subset:  IM    
Section on Clinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Catecholamines / metabolism
Corticotropin-Releasing Hormone / metabolism
Depressive Disorder / physiopathology*,  psychology,  therapy
Electroconvulsive Therapy*
Hydrocortisone / metabolism
Hydroxyindoleacetic Acid / metabolism
Hypothalamo-Hypophyseal System / physiopathology*
Methoxyhydroxyphenylglycol / metabolism
Middle Aged
Neurotransmitter Agents / metabolism*
Pituitary-Adrenal System / physiopathology*
Reg. No./Substance:
0/Catecholamines; 0/Neurotransmitter Agents; 50-23-7/Hydrocortisone; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9015-71-8/Corticotropin-Releasing Hormone

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