Document Detail

Hypothalamic-pituitary-adrenal axis and immune system.
MedLine Citation:
PMID:  7856475     Owner:  NLM     Status:  MEDLINE    
Complex and bidirectional relationships operate between the hypothalamic-pituitary-adrenal (HPA) axis and the immune system (IS) and either in vivo or in vitro evidence supports a physiological role of the HPA axis-IS network. A part of the well-known pharmacological effects of glucocorticoid hormones (GC) as immunodepressive agents, the direct effects of many HPA axis hormones on IS functions are actually documented also in physiologic conditions. Conversely, numerous IS soluble mediators are reported to affect the HPA axis functions at various steps of HPA axis regulation, in both physiologic and pathologic conditions. Stress and aging may represent two paradigmatic conditions to show the relevance of the bidirectional network between HPA axis and IS, as in both HPA activation and IS impairment are frequently coexistent. Finally, in the context of the wide spectrum of HIV-related HPA axis abnormalities, a case of a Cushing's syndrome associated to an acquired immunodeficiency syndrome (AIDS-related complex) in a 24-year-old homosexual drug abuser is reported.
S Savastano; A P Tommaselli; R Valentino; M T Scarpitta; G D'Amore; A Luciano; V Covelli; G Lombardi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta neurologica     Volume:  16     ISSN:  0001-6276     ISO Abbreviation:  Acta Neurol (Napoli)     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421100     Medline TA:  Acta Neurol (Napoli)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  206-13     Citation Subset:  IM; X    
Chair of Endocrinology, C.E.O.S. National Research Council (CNR), Italy.
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MeSH Terms
AIDS-Related Complex / complications,  physiopathology
Adrenocorticotropic Hormone / physiology
Corticotropin-Releasing Hormone / physiology
Cushing Syndrome / complications,  physiopathology
Glucocorticoids / physiology*
Hypothalamo-Hypophyseal System / physiology*
Immune System / physiology*
Neuroimmunomodulation / physiology*
Neurotransmitter Agents / physiology
Pituitary-Adrenal System / physiology*
Rats, Inbred Lew
Reg. No./Substance:
0/Glucocorticoids; 0/Neurotransmitter Agents; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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