Document Detail

Hypothalamic paraventricular nucleus lesions do not abolish glucoprivic or lipoprivic feeding.
MedLine Citation:
PMID:  1467956     Owner:  NLM     Status:  MEDLINE    
This experiment assessed the importance of the hypothalamic paraventricular nucleus (PVN) for feeding stimulated by blockade of glucose utilization (glucoprivic feeding) and fatty acid oxidation (lipoprivic feeding). The PVN was investigated because it is innervated by neurons residing in the area postrema and nucleus of the solitary tract (AP/NTS) region where lesions have been shown to abolish both glucoprivic and lipoprivic feeding, and because the PVN appears to be a site of action for certain feeding-stimulatory peptides and amines. Bilateral electrolytic lesions were placed in the PVN and adjacent areas. Lesioned rats were subsequently tested for feeding in response to 2-deoxy-D-glucose (2DG)-and mercaptoacetate (MA)-induced blockade of glucose and fatty acid oxidation, respectively. Results revealed that total destruction of the PVN does not impair either 2DG- or MA-induced food intake and suggest that this structure is not essential for these particular controls of feeding.
N Y Calingasan; S Ritter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  595     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164-6520.
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MeSH Terms
Deoxyglucose / pharmacology
Eating / drug effects,  physiology*
Fatty Acids / metabolism*
Glucose / metabolism*
Paraventricular Hypothalamic Nucleus / physiology*
Rats, Sprague-Dawley
Thioglycolates / pharmacology
Reg. No./Substance:
0/Fatty Acids; 0/Thioglycolates; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 68-11-1/2-mercaptoacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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