| Hypothalamic paraventricular nucleus lesions do not abolish glucoprivic or lipoprivic feeding. | |
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MedLine Citation:
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PMID: 1467956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This experiment assessed the importance of the hypothalamic paraventricular nucleus (PVN) for feeding stimulated by blockade of glucose utilization (glucoprivic feeding) and fatty acid oxidation (lipoprivic feeding). The PVN was investigated because it is innervated by neurons residing in the area postrema and nucleus of the solitary tract (AP/NTS) region where lesions have been shown to abolish both glucoprivic and lipoprivic feeding, and because the PVN appears to be a site of action for certain feeding-stimulatory peptides and amines. Bilateral electrolytic lesions were placed in the PVN and adjacent areas. Lesioned rats were subsequently tested for feeding in response to 2-deoxy-D-glucose (2DG)-and mercaptoacetate (MA)-induced blockade of glucose and fatty acid oxidation, respectively. Results revealed that total destruction of the PVN does not impair either 2DG- or MA-induced food intake and suggest that this structure is not essential for these particular controls of feeding. |
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Authors:
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N Y Calingasan; S Ritter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 595 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-26 Completed Date: 1993-01-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 25-31 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164-6520. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Deoxyglucose / pharmacology Diet Eating / drug effects, physiology* Fatty Acids / metabolism* Glucose / metabolism* Male Oxidation-Reduction Paraventricular Hypothalamic Nucleus / physiology* Rats Rats, Sprague-Dawley Thioglycolates / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Thioglycolates; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 68-11-1/2-mercaptoacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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