Document Detail


Hypothalamic paraventricular nucleus lesions do not abolish glucoprivic or lipoprivic feeding.
MedLine Citation:
PMID:  1467956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This experiment assessed the importance of the hypothalamic paraventricular nucleus (PVN) for feeding stimulated by blockade of glucose utilization (glucoprivic feeding) and fatty acid oxidation (lipoprivic feeding). The PVN was investigated because it is innervated by neurons residing in the area postrema and nucleus of the solitary tract (AP/NTS) region where lesions have been shown to abolish both glucoprivic and lipoprivic feeding, and because the PVN appears to be a site of action for certain feeding-stimulatory peptides and amines. Bilateral electrolytic lesions were placed in the PVN and adjacent areas. Lesioned rats were subsequently tested for feeding in response to 2-deoxy-D-glucose (2DG)-and mercaptoacetate (MA)-induced blockade of glucose and fatty acid oxidation, respectively. Results revealed that total destruction of the PVN does not impair either 2DG- or MA-induced food intake and suggest that this structure is not essential for these particular controls of feeding.
Authors:
N Y Calingasan; S Ritter
Related Documents :
10732726 - Essential fatty acids and related molecular and cellular mechanisms in multiple scleros...
6134556 - Acyl group composition of lipids and the activities of (na+ + k+)-atpase, 5'-nucleotida...
12892896 - Chitin synthase iii activity, but not the chitin ring, is required for remedial septa f...
7172626 - Fatty acid composition of synaptosomes from normal and cobalamin deficient bat brain.
16980726 - Hydroxyeicosatetraenoic acids released through the cytochrome p-450 pathway regulate 3t...
22055346 - Effect of body fat distribution on the fatty acid composition of the depot fat of cattle.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  595     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Affiliation:
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164-6520.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Deoxyglucose / pharmacology
Diet
Eating / drug effects,  physiology*
Fatty Acids / metabolism*
Glucose / metabolism*
Male
Oxidation-Reduction
Paraventricular Hypothalamic Nucleus / physiology*
Rats
Rats, Sprague-Dawley
Thioglycolates / pharmacology
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Thioglycolates; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 68-11-1/2-mercaptoacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurons in the dorsal column nuclei of the rat respond to stimulation of neck mechanoreceptors and p...
Next Document:  Axial muscle EMG responses evoked by cutaneous flank nerves in the female rat: effects of spinal tra...