| Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. | |
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MedLine Citation:
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PMID: 12948845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03 nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin. |
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Authors:
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Pawel K Olszewski; Martha K Grace; Charles J Billington; Allen S Levine |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 24 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2004-06-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 919-23 Citation Subset: IM |
Affiliation:
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Veterans Affairs Medical Center, 1 Veterans Drive, Research Route 151, Minneapolis, MN 55417, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Feeding Behavior / drug effects* Ghrelin Hypothalamus / drug effects, physiology Immunohistochemistry Injections, Intraventricular Male NG-Nitroarginine Methyl Ester / pharmacology Peptide Hormones / administration & dosage, pharmacology* Proto-Oncogene Proteins c-fos / analysis*, immunology* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DA-03999/DA/NIDA NIH HHS; DK-42698/DK/NIDDK NIH HHS; P30 DK-50456/DK/NIDDK NIH HHS; T32DA07097/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 0/Proto-Oncogene Proteins c-fos; 50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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