Document Detail


Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity.
MedLine Citation:
PMID:  12948845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03 nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin.
Authors:
Pawel K Olszewski; Martha K Grace; Charles J Billington; Allen S Levine
Related Documents :
9662085 - Leptin (ob) mrna and hypothalamic npy in food-deprived/refed syrian hamsters.
20825365 - Neuroadipology: a novel component of neuroendocrinology.
18536705 - Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through...
18708095 - Triiodothyronine (t3) stimulates food intake via enhanced hypothalamic amp-activated ki...
2595245 - Effect of haem arginate on colony formation by haematopoietic progenitors in vitro.
12471435 - Dynamics of evolution and resistance to starvation of triatoma vitticeps (stal 1859) (r...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  24     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-06-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  919-23     Citation Subset:  IM    
Affiliation:
Veterans Affairs Medical Center, 1 Veterans Drive, Research Route 151, Minneapolis, MN 55417, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Ghrelin
Hypothalamus / drug effects,  physiology
Immunohistochemistry
Injections, Intraventricular
Male
NG-Nitroarginine Methyl Ester / pharmacology
Peptide Hormones / administration & dosage,  pharmacology*
Proto-Oncogene Proteins c-fos / analysis*,  immunology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DA-03999/DA/NIDA NIH HHS; DK-42698/DK/NIDDK NIH HHS; P30 DK-50456/DK/NIDDK NIH HHS; T32DA07097/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Proto-Oncogene Proteins c-fos; 50903-99-6/NG-Nitroarginine Methyl Ester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ghrelin-induced feeding is dependent on nitric oxide.
Next Document:  Electron microscopic examination of the orexin immunoreactivity in the dorsal raphe nucleus.