Document Detail

Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
MedLine Citation:
PMID:  12797956     Owner:  NLM     Status:  MEDLINE    
Mammals respond to reduced food availability by becoming more wakeful and active, yet the central pathways regulating arousal and instinctual motor programs (such as food seeking) according to homeostatic need are not well understood. We demonstrate that hypothalamic orexin neurons monitor indicators of energy balance and mediate adaptive augmentation of arousal in response to fasting. Activity of isolated orexin neurons is inhibited by glucose and leptin and stimulated by ghrelin. Orexin expression of normal and ob/ob mice correlates negatively with changes in blood glucose, leptin, and food intake. Transgenic mice, in which orexin neurons are ablated, fail to respond to fasting with increased wakefulness and activity. These findings indicate that orexin neurons provide a crucial link between energy balance and arousal.
Akihiro Yamanaka; Carsten T Beuckmann; Jon T Willie; Junko Hara; Natsuko Tsujino; Michihiro Mieda; Makoto Tominaga; Ken ichi Yagami; Fumihiro Sugiyama; Katsutoshi Goto; Masashi Yanagisawa; Takeshi Sakurai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  38     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-07-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-13     Citation Subset:  IM    
Institute of Basic Medical Science, University of Tsukuba, 305-8575, Ibaraki, Japan.
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MeSH Terms
Arousal / drug effects,  genetics*
Blood Glucose / drug effects,  physiology
Carrier Proteins / genetics
Energy Metabolism / drug effects,  genetics*
Exploratory Behavior / drug effects,  physiology
Extracellular Space / metabolism
Food Deprivation / physiology*
Glucose / metabolism,  pharmacology
Green Fluorescent Proteins
Homeostasis / drug effects,  genetics
Hunger / drug effects,  physiology*
Hypothalamus / cytology,  drug effects,  metabolism*
Intracellular Signaling Peptides and Proteins*
Leptin / metabolism,  pharmacology
Luminescent Proteins / diagnostic use
Membrane Potentials / genetics
Mice, Transgenic
Neurons / cytology,  drug effects,  metabolism*
Neuropeptides / deficiency*,  genetics
Organ Culture Techniques
Peptide Hormones / metabolism,  pharmacology
Recombinant Fusion Proteins / diagnostic use
Synaptic Transmission / genetics
Transgenes / genetics
Reg. No./Substance:
0/Blood Glucose; 0/Carrier Proteins; 0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Luminescent Proteins; 0/Neuropeptides; 0/Peptide Hormones; 0/Recombinant Fusion Proteins; 0/orexins; 147336-22-9/Green Fluorescent Proteins; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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