| Hypothalamic obesity syndrome: Rare presentation of CNS+ B-cell lymphoblastic lymphoma. | |
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MedLine Citation:
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PMID: 22213612 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This syndrome is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS+ B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. We describe a novel presentation of hypothalamic obesity syndrome in CNS B-cell lymphoblastic lymphoma, responsive to chemotherapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. |
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Authors:
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Troy C Quigg; Nadine G Haddad; Jeffrey C Buchsbaum; Chie-Schin Shih |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-27 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Section of Pediatric Hematology/Oncology, Riley Hospital for Children, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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