Document Detail


Hypothalamic neural circuits regulating maternal responsiveness toward infants.
MedLine Citation:
PMID:  17099111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A theoretical neural model is developed, along with supportive evidence, to explain how the medial preoptic area (MPOA) of the hypothalamus can regulate maternal responsiveness toward infant-related stimuli. It is proposed that efferents from a hormone-primed MPOA (a) depress a central aversion system (composed of neural circuits between the amygdala, medial hypothalamus, and midbrain) so that novel infant stimuli do not activate defensive or avoidance behavior and (b) excite the mesolimbic dopamine system so that active, voluntary maternal responses are promoted. The effects of oxytocin and maternal experience are included in the model, and the specificity of MPOA effects are discussed. The model may be relevant to the mechanisms through which other hypothalamic nuclei regulate other basic motivational states. In addition, aspects of the model may define a core neural circuitry for maternal behavior in mammals.
Authors:
Michael Numan
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Behavioral and cognitive neuroscience reviews     Volume:  5     ISSN:  1534-5823     ISO Abbreviation:  Behav Cogn Neurosci Rev     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120119     Medline TA:  Behav Cogn Neurosci Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-90     Citation Subset:  IM    
Affiliation:
Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA. numan@bc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Animals
Dopamine / physiology*
Female
Humans
Mammals
Maternal Behavior / physiology*
Mother-Child Relations
Neural Pathways / cytology,  physiology*
Preoptic Area / physiology*
Rats
Septal Nuclei / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predictors of resident outcome improvement in nursing homes.
Next Document:  Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery af...