Document Detail


Hypothalamic infusion of the 5-HT2/1C agonist, DOI, prevents the inhibitory actions of the 5-HT1A agonist, 8-OH-DPAT, on lordosis behavior.
MedLine Citation:
PMID:  8208763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sexually receptive, intact, proestrous rats were infused bilaterally into the ventromedial nucleus of the hypothalamus (VMN) with 200 ng of the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), with 2000 ng of the 5-HT2/1C agonist, (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or with both 8-OH-DPAT and DOI. Alone, VMN infusions of 8-OH-DPAT, but not DOI, inhibited lordosis behavior. When 2000 ng DOI was infused simultaneously with 8-OH-DPAT, the inhibitory effects of 8-OH-DPAT were completely abolished. These results suggest that neural sites responsible for the reported facilitatory effects of 5-HT2/1C agonists on lordosis behavior coexist in the VMN with those sites in which 5-HT1A agonists are effective in reducing lordosis behavior. In contrast to the protective action of the 5-HT2/1C receptor agonist following VMN infusion, no protection was seen when both DOI and 8-OH-DPAT were administered intraperitoneally. Thus, the interaction of these two receptor subtypes in the control of lordosis behavior may be different in regions outside the VMN.
Authors:
L Uphouse; M Andrade; M Caldarola-Pastuszka; S Maswood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  47     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM; S    
Affiliation:
Department of Biology, Texas Woman's University, Denton 76204.
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage,  antagonists & inhibitors*,  pharmacology
Amphetamines / administration & dosage,  pharmacology*
Animals
Female
Injections
Injections, Intraperitoneal
Posture / physiology*
Proestrus / physiology
Rats
Rats, Inbred F344
Serotonin Agonists / administration & dosage,  pharmacology*
Sexual Behavior, Animal / drug effects*
Ventromedial Hypothalamic Nucleus / anatomy & histology,  physiology*
Grant Support
ID/Acronym/Agency:
GM08256/GM/NIGMS NIH HHS; R01 HD28419/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Serotonin Agonists; 64584-34-5/4-iodo-2,5-dimethoxyphenylisopropylamine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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