| Hypothalamic hypothyroidism causing spastic paraplegia: recovery following thyroid medication. | |
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MedLine Citation:
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PMID: 727728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 63-year-old woman with longstanding spastic paraplegia and neurological evidence of long tract disturbance was found to have hypothyroidism, partial diabetes insipidus, hyperprolactinemia, and gonadotropin deficiency of hypothalamic origin. Replacement therapy with thyroxine and prednisone induced complete remission of the neurological abnormalities. The association of spastic paraplegia with hypothalamic insufficiency has not been reported previously. The possibility of hypothalamic disease should be considered in cases of spastic paraplegia of unknown cause. |
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Authors:
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I M Jackson; P D Papapetrou; J R Hills; M Kassirer |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of neurology Volume: 3 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1978 May |
Date Detail:
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Created Date: 1979-02-21 Completed Date: 1979-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 458-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
/
complications,
therapy Diabetes Insipidus / complications Female Humans Hypothalamus* Hypothyroidism / complications*, drug therapy, etiology Middle Aged Muscle Spasticity / etiology, therapy Paraplegia / etiology*, therapy Thyroxine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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