Document Detail

Hypothalamic-hypophyseal dysgenesis as a neuroimaging correlate of pituitary hormone deficiency in anophthalmia.
MedLine Citation:
PMID:  8909226     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To document the association of neurohypophyseal dysgenesis with hypopituitarism in a child with primary bilateral anophthalmia. METHODS: An infant with bilateral anophthalmia underwent magnetic resonance imaging and endocrinologic evaluation. RESULTS: Magnetic resonance imaging showed dysgenesis confined to the hypothalamus and hypophyseal stalk. Endocrinologic testing showed low serum cortisol and pituitary gonadotropin levels. CONCLUSION: Magnetic resonance imaging can help predict which children with anophthalmia will have endocrinologic deficiencies.
M C Brodsky; J P Frindik
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  122     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-8     Citation Subset:  AIM; IM    
Department of Ophthalmology, University of Arkansas for Medical Sciences, USA.
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MeSH Terms
Abnormalities, Multiple / blood,  genetics*
Anophthalmos / blood,  genetics*
Gonadotropins, Pituitary / blood,  deficiency
Hydrocortisone / blood,  deficiency
Hypopituitarism / blood,  diagnosis*,  genetics
Hypothalamo-Hypophyseal System / abnormalities*,  pathology*
Infant, Newborn
Magnetic Resonance Imaging
Pituitary Hormones / blood,  deficiency*
Reg. No./Substance:
0/Gonadotropins, Pituitary; 0/Pituitary Hormones; 50-23-7/Hydrocortisone

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