| Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications. | |
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MedLine Citation:
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PMID: 18019608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by cognitive, psychiatric, behavioural and motor disturbances. Although the course of HD is also frequently complicated by unintended weight loss, sleep disturbances and autonomic nervous system dysfunction, the aetiology of these signs and symptoms remains largely unknown. In recent years, many novel findings from both animal and human studies have emerged that indicate considerable hypothalamic, endocrine and metabolic alterations in HD. However, a comprehensive overview of these findings is lacking and their precise clinical significance is far from clear. Therefore, in this review we attempt to put these recent developments in the field into perspective by integrating them with previous findings in a comprehensible manner, and by discussing their clinical relevance, with a special focus on body weight, sleep and autonomic functions in HD, which will also allow for the identification of future lines of research in this area. |
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Authors:
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N A Aziz; D F Swaab; H Pijl; R A C Roos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in the neurosciences Volume: 18 ISSN: 0334-1763 ISO Abbreviation: Rev Neurosci Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2007-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8711016 Medline TA: Rev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 223-51 Citation Subset: IM |
Affiliation:
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Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands. N.A.Aziz.Neur@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System Diseases / etiology, metabolism, physiopathology* Endocrine System Diseases / etiology, metabolism, physiopathology* Humans Huntington Disease / complications, metabolism, physiopathology* Hypothalamic Diseases / etiology, metabolism, physiopathology* Hypothalamo-Hypophyseal System / metabolism, physiopathology, secretion Metabolic Diseases / etiology, metabolism, physiopathology Neurosecretory Systems / metabolism, physiopathology Sleep Disorders / etiology, metabolism, physiopathology |
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