Document Detail

Hypothalamic digoxin, hemispheric dominance, and neuroimmune integration.
MedLine Citation:
PMID:  12325397     Owner:  NLM     Status:  MEDLINE    
The isoprenoid pathway produces three key metabolites--digoxin (membrane Na(+)-K+ ATPase inhibitor, regulator of neurotransmitter transport, and immunomodulatory agent), dolichol (regulatory of N-glycosylation of proteins), and ubiquinone (free-radical scavenger). The pathway was assessed in systemic lupus erythematosis with neuropsychiatric manifestations, slow viral diseases (subacute sclerosing panencephalitis [SSPE], and Creutzfeldt-Jakob disease [CJD]) and patients with recurrent respiratory infections. This was also studied for comparison in patients with right hemispheric and left hemispheric dominance. The isoprenoid pathway was upregulated with increased digoxin synthesis in patients with neurolupus, SSPE, and CJD, and in those with right hemispheric dominance. The tryptophan catabolites were increased and the tyrosine catabolites reduced. In these patients the dolichol and glycoconjugate levels were elevated and lysosomal stability was reduced. The ubiquinone levels were low and free-radical levels increased in these patients. The membrane cholesterol:phospholipid ratios were increased and membrane glycoconjugates reduced. On the other hand, in patients with recurrent respiratory infection and left hemispheric dominance, the reverse patterns and hypodigoxinemia with a downregulated isoprenoid pathway were noticed. The isoprenoid pathway is important in the pathogenesis of neurolupus, CJD, SSPE, and recurrent respiratory infections. Hypothalamic digoxin and chemical hemispheric dominance play an important role in the regulation of immunity.
Ravi Kumar Kurup; Parameswara Achutha Kurup
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  112     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2003-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-62     Citation Subset:  IM    
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
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MeSH Terms
Creutzfeldt-Jakob Syndrome / metabolism,  physiopathology
Digoxin / metabolism*
Dolichol / blood
Erythrocyte Membrane / enzymology
Functional Laterality*
Glycosaminoglycans / metabolism
Hydroxymethylglutaryl CoA Reductases / blood
Hypothalamus / metabolism*,  physiopathology
Lupus Erythematosus, Systemic / complications,  metabolism,  physiopathology
Mental Disorders / etiology
Respiratory Tract Diseases / metabolism,  physiopathology
Sodium-Potassium-Exchanging ATPase / blood
Subacute Sclerosing Panencephalitis / metabolism,  physiopathology
Tryptophan / metabolism
Tyrosine / metabolism
Ubiquinone / blood
Reg. No./Substance:
0/Glycosaminoglycans; 1339-63-5/Ubiquinone; 2067-66-5/Dolichol; 20830-75-5/Digoxin; 55520-40-6/Tyrosine; 73-22-3/Tryptophan; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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