Document Detail

Hypothalamic digoxin, hemispheric chemical dominance, and interstitial lung disease.
MedLine Citation:
PMID:  14534040     Owner:  NLM     Status:  MEDLINE    
The isoprenoid pathway produces three key metabolites--endogenous digoxin, dolichol, and ubiquinone. This was assessed in patients with idiopathic pulmonary fibrosis and in individuals of differing hemispheric dominance to find out the role of hemispheric dominance in the pathogenesis of idiopathic pulmonary fibrosis. All 15 cases of interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. The isoprenoidal metabolites--digoxin, dolichol, and ubiquinone, RBC membrane Na(+)-K+ ATPase activity, serum magnesium, tyrosine/tryptophan catabolic patterns, free radical metabolism, glycoconjugate metabolism, and RBC membrane composition--were assessed in idiopathic pulmonary fibrosis as well as in individuals with differing hemispheric dominance. In patients with idiopathic pulmonary fibrosis there was elevated digoxin synthesis, increased dolichol and glycoconjugate levels, and low ubiquinone and elevated free radical levels. There was also an increase in tryptophan catabolites and a reduction in tyrosine catabolites. There was an increase in cholesterol phospholipid ratio and a reduction in glycoconjugate level of RBC membrane in patients with idiopathic pulmonary fibrosis. Isoprenoid pathway dysfunction con tributes to the pathogenesis of idiopathic pulmonary fibrosis. The biochemical patterns obtained in interstitial lung disease are similar to those obtained in left-handed/right hemispheric chemically dominant individuals by the dichotic listening test. However, all the patients with interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. Hemispheric chemical dominance has no correlation with handedness or the dichotic listening test. Interstitial lung disease occurs in right hemispheric chemically dominant individuals and is a reflection of altered brain function.
Ravi Kumar Kurup; Parameswara Achutha Kurup
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  113     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-09     Completed Date:  2003-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1427-43     Citation Subset:  IM    
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
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MeSH Terms
Adenosine Triphosphatases / metabolism
Brain Chemistry*
Case-Control Studies
Dichotic Listening Tests
Digoxin / blood,  metabolism*
Dolichol / metabolism
Dominance, Cerebral*
Free Radicals / metabolism
Glycoconjugates / metabolism
Hydroxymethylglutaryl CoA Reductases / metabolism
Hypothalamus / chemistry,  metabolism*
Isoproterenol / metabolism
Lung Diseases / classification,  metabolism*
Magnesium / metabolism
Middle Aged
Neurotransmitter Agents / metabolism
Saponins / blood
Ubiquinone / metabolism
Reg. No./Substance:
0/Cardenolides; 0/Free Radicals; 0/Glycoconjugates; 0/Neurotransmitter Agents; 0/Saponins; 0/digoxin-like factors; 1339-63-5/Ubiquinone; 2067-66-5/Dolichol; 20830-75-5/Digoxin; 7439-95-4/Magnesium; 7683-59-2/Isoproterenol; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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