| Hypothalamic digoxin, hemispheric chemical dominance, and interstitial lung disease. | |
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MedLine Citation:
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PMID: 14534040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The isoprenoid pathway produces three key metabolites--endogenous digoxin, dolichol, and ubiquinone. This was assessed in patients with idiopathic pulmonary fibrosis and in individuals of differing hemispheric dominance to find out the role of hemispheric dominance in the pathogenesis of idiopathic pulmonary fibrosis. All 15 cases of interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. The isoprenoidal metabolites--digoxin, dolichol, and ubiquinone, RBC membrane Na(+)-K+ ATPase activity, serum magnesium, tyrosine/tryptophan catabolic patterns, free radical metabolism, glycoconjugate metabolism, and RBC membrane composition--were assessed in idiopathic pulmonary fibrosis as well as in individuals with differing hemispheric dominance. In patients with idiopathic pulmonary fibrosis there was elevated digoxin synthesis, increased dolichol and glycoconjugate levels, and low ubiquinone and elevated free radical levels. There was also an increase in tryptophan catabolites and a reduction in tyrosine catabolites. There was an increase in cholesterol phospholipid ratio and a reduction in glycoconjugate level of RBC membrane in patients with idiopathic pulmonary fibrosis. Isoprenoid pathway dysfunction con tributes to the pathogenesis of idiopathic pulmonary fibrosis. The biochemical patterns obtained in interstitial lung disease are similar to those obtained in left-handed/right hemispheric chemically dominant individuals by the dichotic listening test. However, all the patients with interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. Hemispheric chemical dominance has no correlation with handedness or the dichotic listening test. Interstitial lung disease occurs in right hemispheric chemically dominant individuals and is a reflection of altered brain function. |
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Authors:
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Ravi Kumar Kurup; Parameswara Achutha Kurup |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The International journal of neuroscience Volume: 113 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-09 Completed Date: 2003-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1427-43 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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metabolism Brain Chemistry* Cardenolides Case-Control Studies Dichotic Listening Tests Digoxin / blood, metabolism* Dolichol / metabolism Dominance, Cerebral* Free Radicals / metabolism Glycoconjugates / metabolism Humans Hydroxymethylglutaryl CoA Reductases / metabolism Hypothalamus / chemistry, metabolism* Isoproterenol / metabolism Lung Diseases / classification, metabolism* Magnesium / metabolism Middle Aged Neurotransmitter Agents / metabolism Saponins / blood Ubiquinone / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cardenolides; 0/Free Radicals; 0/Glycoconjugates; 0/Neurotransmitter Agents; 0/Saponins; 0/digoxin-like factors; 1339-63-5/Ubiquinone; 2067-66-5/Dolichol; 20830-75-5/Digoxin; 7439-95-4/Magnesium; 7683-59-2/Isoproterenol; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 3.6.1.-/Adenosine Triphosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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