Document Detail

Hypothalamic clocks and rhythms in feeding behaviour.
MedLine Citation:
PMID:  23333345     Owner:  NLM     Status:  MEDLINE    
Daily rhythms are evident across our physiology, ranging from overt behavioural patterns like sleep to intricate molecular rhythms in epigenetic coding. Driving these rhythms at an anatomical and cellular level are circadian clock networks comprising core clock genes and an ever-expanding list of clock-controlled genes. Research over the past decade has revealed an intimate relationship between the clockwork and metabolic processes. In line with this, feeding behaviour in many species exhibits a strong circadian rhythm and, when restricted, food becomes the most potent entraining stimulus for clocks of the body. Critically, there are several indications that disturbance of our daily rhythms contributes to the development of obesity and diabetes. Given our 24-h society, it is important that we understand how the circadian clock influences what and when we eat.
David A Bechtold; Andrew S I Loudon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-18
Journal Detail:
Title:  Trends in neurosciences     Volume:  36     ISSN:  1878-108X     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-31     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  74-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Circadian Clocks / physiology*
Circadian Rhythm / physiology*
Eating / physiology
Feeding Behavior / physiology*
Hypothalamus / physiology*
Grant Support
BB/I018654/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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