| Hypothalamic and plasmatic angiotensin metabolism in L-NAME treated rats. | |
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MedLine Citation:
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PMID: 20049672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to study the interaction between the renin-angiotensin system (RAS) and nitric oxide (NO), we analyzed the activity of aspartyl- (AspAP), glutamyl- (GluAP), alanyl- (AlaAP), and cystinylaminopeptidase (CysAP) enzymes involved in the RAS cascade, in the hypothalamus, and plasma of normotensive adult male rats after the inhibition of NO production with the NO synthase inhibitor L-NAME (L-N (G)-nitroarginine methyl ester). L-NAME treatment produced a significant increase of systolic blood pressure (SBP). In plasma, while GluAP activity decreased significantly, suggesting a lower Ang III formation, the other aminopeptidases did not change after L-NAME treatment. In hypothalamus, the activities of AspAP and CysAP were not affected after L-NAME treatment. In contrast, GluAP and AlaAP increased significantly. These results suggested mainly a higher formation of Ang III, but also higher levels of Ang IV in the hypothalamus of L-NAME treated rats. Both peptides have hypertensive properties at central level. On the contrary, Ang III may counteract the hypertensive action of Ang II at the periphery. Therefore, the increased SBP in L-NAME treated rats may be due in part to the increased activity of GluAP and AlaAP in hypothalamus and to a decreased activity of GluAP in plasma. |
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Authors:
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A B Segarra; M Ram?rez; A B Villarejo; I Banegas; F Vives; M de Gasparo; F Alba; J Cobo; I Prieto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-04 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 222-4 Citation Subset: IM |
Affiliation:
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Unit of Physiology, Department of Health Sciences, University of Ja?n, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminopeptidases
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blood Angiotensins / blood*, metabolism* Animals Blood Pressure / drug effects Hypothalamus / drug effects*, enzymology, metabolism* NG-Nitroarginine Methyl Ester / pharmacology* Rats Rats, Wistar Renin-Angiotensin System / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensins; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 3.4.11.-/Aminopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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