| Hypothalamic Kappa Opioid Receptor Modulates the Orexigenic Effect of Ghrelin. | |
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MedLine Citation:
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PMID: 23348063 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches we demonstrate that ghrelin utilizes a hypothalamic kappa opioid receptor (KOR) pathway to increase food intake in rats. Pharmacological blockade of KOR decreases the acute orexigenic effect of ghrelin. Inhibition of KOR expression in the hypothalamic arcuate nucleus is sufficient to blunt ghrelin-induced food intake. By contrast, the specific inhibition of KOR expression in the ventral tegmental area does not affect central ghrelin-induced feeding. This new pathway is independent of ghrelin-induced AMPK activation, but modulates the levels of the transcription factors and orexigenic neuropeptides triggered by ghrelin to finally stimulate feeding. Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin.Neuropsychopharmacology accepted article preview online, 24 January 2013; doi:10.1038/npp.2013.28. |
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Authors:
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Amparo Romero-Picó; Maria J Vázquez; David González-Touceda; Cintia Folgueira; Karolina P Skibicka; Mayte Alvarez-Crespo; Margriet A Van Gestel; Douglas A Velásquez; Christoph Schwarzer; Herbert Herzog; Miguel López; Roger A Adan; Suzanne L Dickson; Carlos Diéguez; Rubén Nogueiras |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: - ISSN: 1740-634X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology, School of Medicine-CIMUS - Instituto de Investigaciones Sanitarias (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), University of Santiago de Compostela, Santiago de Compostela, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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