Document Detail


Hypothalamic Kappa Opioid Receptor Modulates the Orexigenic Effect of Ghrelin.
MedLine Citation:
PMID:  23348063     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches we demonstrate that ghrelin utilizes a hypothalamic kappa opioid receptor (KOR) pathway to increase food intake in rats. Pharmacological blockade of KOR decreases the acute orexigenic effect of ghrelin. Inhibition of KOR expression in the hypothalamic arcuate nucleus is sufficient to blunt ghrelin-induced food intake. By contrast, the specific inhibition of KOR expression in the ventral tegmental area does not affect central ghrelin-induced feeding. This new pathway is independent of ghrelin-induced AMPK activation, but modulates the levels of the transcription factors and orexigenic neuropeptides triggered by ghrelin to finally stimulate feeding. Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin.Neuropsychopharmacology accepted article preview online, 24 January 2013; doi:10.1038/npp.2013.28.
Authors:
Amparo Romero-Picó; Maria J Vázquez; David González-Touceda; Cintia Folgueira; Karolina P Skibicka; Mayte Alvarez-Crespo; Margriet A Van Gestel; Douglas A Velásquez; Christoph Schwarzer; Herbert Herzog; Miguel López; Roger A Adan; Suzanne L Dickson; Carlos Diéguez; Rubén Nogueiras
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  -     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Physiology, School of Medicine-CIMUS - Instituto de Investigaciones Sanitarias (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), University of Santiago de Compostela, Santiago de Compostela, Spain.
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