Document Detail

Hypothalamic Histaminergic and Orexinergic Modulation on Cerebellar and Vestibular Motor Control.
MedLine Citation:
PMID:  23299849     Owner:  NLM     Status:  Publisher    
Somatic-nonsomatic integration is critical for generation and execution of an appropriate and coordinated behavioral response to changes in internal and external environments. However, the underlying neural substrates and mechanisms are still enigmatic. Intriguingly, the central histaminergic and orexinergic systems originating from the hypothalamus, a high autonomic regulatory center, innervate almost the whole brain including various subcortical motor structures, particularly the cerebellum and vestibular nuclei. Here, we suggest that the hypothalamic histaminergic and orexinergic system bridging the nonsomatic center to somatic motor structures may actively modulate the cerebellar and vestibular nuclear neurons and subsequently participate in motor control and somatic-nonsomatic integration.
Xiao-Yang Zhang; Lei Yu; Qian-Xing Zhuang; Jun Zhang; Jing-Ning Zhu; Jian-Jun Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Cerebellum (London, England)     Volume:  -     ISSN:  1473-4230     ISO Abbreviation:  Cerebellum     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101089443     Medline TA:  Cerebellum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Mailbox 426, 22 Hankou Road, Nanjing, 210093, China.
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