Document Detail

Hypothalamic Galanin-like Peptide (GALP) Rescues the Onset of Puberty in Food-Restricted Weanling Rats.
MedLine Citation:
PMID:  22681480     Owner:  NLM     Status:  Publisher    
Galanin-like peptide (GALP) is a known mediator of metabolism and reproduction; however, the role GALP plays in the onset of puberty is unknown. First, we tested the hypothesis that central GALP administration could rescue puberty in food-restricted weanling rats. GALP treatment in food-restricted rats of both sexes rescued the timing of the onset of puberty to that seen in ad lib fed controls. Second, we tested whether GALP translation knocked-down in ad lib fed, prepubertal rats would alter the timing of puberty. Knock-down females, but not males, showed a significant (P < 0.01) delay in the onset of puberty compared to controls. Third, we sought evidence that GALP's role in pubertal onset is mediated by the kisspeptin system. In situ hybridization analyses showed a significant (P < 0.01) reduction in Kiss1 mRNA within the hypothalamic arcuate nucleus in food-restricted rats compared to ad lib fed controls and that this reduction was prevented with intracerebroventricular (ICV) GALP administration. Furthermore, analyses of Fos-ir expression following ICV GALP treatment did not elicit Fos-ir within any kisspeptin neurons, nor are GALP and kisspeptin peptides or mRNA colcoalized. These data demonstrate that hypothalamic GALP infusion maintained the onset of puberty in food-restricted weanling rats, but probably not via direct innervation of kisspeptin neurons. Published 2012 This article is a US Government work and is in the public domain in the USA.
M A Mohr; E Leathley; G S Fraley
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-8
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of Neuroendocrinology © 2012 Blackwell Publishing Ltd.
Biology Department and Neuroscience Program, Hope College, Holland, MI.
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