Document Detail


Hypothalamic GABA receptor functional regulation and liver cell proliferation.
MedLine Citation:
PMID:  11216865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GABAergic alterations in hypothalamus during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN) induced direct hyperplasia and N-nitrosodiethylamine (NDEA) induced neoplasia in liver were investigated. Serum GABA levels were increased in all 3 experimental groups compared with the control. GABA content decreased in hypothalamus of PH and NDEA treated rats, while it increased in LN treated rats. GABA(A) receptor number and affinity in hypothalamic membrane preparations of rats showed a significant decrease in PH and NDEA treated rats, while in LN treated rats the affinity increased without any change in the receptor number. The GABA(B) receptor number increased in PH and NDEA treated rats, while it decreased in LN treated rats. The affinity of the receptor also increased in NDEA treated rats. Plasma NE levels showed significant increase in PH and NDEA rats compared with the control while it decreased in LN treated rats. The results of the present study suggests that liver cell proliferation is influencing the hypothalamic GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.
Authors:
M P Biju; S Pyroja; N V Rajeshkumar; C S Paulose
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  216     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-16     Completed Date:  2001-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, India.
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MeSH Terms
Descriptor/Qualifier:
Alkylating Agents / pharmacology
Animals
Cell Division
Chromatography, High Pressure Liquid
Diethylnitrosamine / pharmacology
Hyperplasia / chemically induced,  metabolism
Hypothalamus / metabolism*
Kinetics
Lead / pharmacology
Liver / cytology*
Liver Neoplasms / chemically induced,  metabolism
Male
Mitogens / pharmacology
Nitrates / pharmacology
Norepinephrine / blood
Protein Binding
Rats
Rats, Wistar
Receptors, GABA / metabolism*
gamma-Aminobutyric Acid / blood
Chemical
Reg. No./Substance:
0/Alkylating Agents; 0/Mitogens; 0/Nitrates; 0/Receptors, GABA; 18256-98-9/lead nitrate; 51-41-2/Norepinephrine; 55-18-5/Diethylnitrosamine; 56-12-2/gamma-Aminobutyric Acid; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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