Document Detail

Hypothalamic GABA receptor functional regulation and liver cell proliferation.
MedLine Citation:
PMID:  11216865     Owner:  NLM     Status:  MEDLINE    
GABAergic alterations in hypothalamus during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN) induced direct hyperplasia and N-nitrosodiethylamine (NDEA) induced neoplasia in liver were investigated. Serum GABA levels were increased in all 3 experimental groups compared with the control. GABA content decreased in hypothalamus of PH and NDEA treated rats, while it increased in LN treated rats. GABA(A) receptor number and affinity in hypothalamic membrane preparations of rats showed a significant decrease in PH and NDEA treated rats, while in LN treated rats the affinity increased without any change in the receptor number. The GABA(B) receptor number increased in PH and NDEA treated rats, while it decreased in LN treated rats. The affinity of the receptor also increased in NDEA treated rats. Plasma NE levels showed significant increase in PH and NDEA rats compared with the control while it decreased in LN treated rats. The results of the present study suggests that liver cell proliferation is influencing the hypothalamic GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.
M P Biju; S Pyroja; N V Rajeshkumar; C S Paulose
Related Documents :
1300045 - Effects of exogenous gamma-aminobutyric acid on experimental arrhythmias.
19747495 - Reduced expression of glutamate transporters vglut1, eaat2 and eaat4 in learned helples...
20807585 - The effects of midazolam and d-cycloserine on the release of glutamate and gaba in the ...
6843905 - The effects of phencyclidine on glutamic acid decarboxylase activity in several regions...
22427945 - In vivo manganese exposure modulates erk, akt and darpp-32 in the striatum of developin...
9464655 - Alpha2-adrenoceptor agonist medetomidine affects the melatonin rhythm in rats.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  216     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-16     Completed Date:  2001-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkylating Agents / pharmacology
Cell Division
Chromatography, High Pressure Liquid
Diethylnitrosamine / pharmacology
Hyperplasia / chemically induced,  metabolism
Hypothalamus / metabolism*
Lead / pharmacology
Liver / cytology*
Liver Neoplasms / chemically induced,  metabolism
Mitogens / pharmacology
Nitrates / pharmacology
Norepinephrine / blood
Protein Binding
Rats, Wistar
Receptors, GABA / metabolism*
gamma-Aminobutyric Acid / blood
Reg. No./Substance:
0/Alkylating Agents; 0/Mitogens; 0/Nitrates; 0/Receptors, GABA; 18256-98-9/lead nitrate; 51-41-2/Norepinephrine; 55-18-5/Diethylnitrosamine; 56-12-2/gamma-Aminobutyric Acid; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term gemfibrozil treatment reverses lipid profile and peroxidation but does not alter blood gl...
Next Document:  Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat wh...