Document Detail


Hypotensive and vascular effects of labetalol in the normotensive rat and dog.
MedLine Citation:
PMID:  32409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new antihypertensive agent, labetalol, has potent hypotensive effects in the anesthetized rat and dog when given intravenously and also in the unanesthetized beagle when given orally. Labetalol slightly increased renal blood flow of the anesthetized dog while decreasing blood pressure. Labetalol slightly increased blood flow of canine femoral artery under constant pressure perfusion. However as compared with hydralazine, labetalol seems to have no marked vasodilatatory effect which accounts for its hypotensive effect. Pharmacologically, labetalol possessed both alpha- and beta-blocking activities, though weaker than phentolamine and propranolol respectively. Another specific action of labetalol was that it has stronger beta-blocking action on beta1 receptor (heart rate response) than on beta2 receptor (blood pressure response). Like several other beta-blockers, labetalol seems to block neuronal uptake of noradrenaline.
Authors:
K Hashimoto; T Hashimoto; H Iizuka; T Tsukada; H Matsuda; S Imai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  19     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-03-28     Completed Date:  1979-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  762-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Animals
Blood Flow Velocity
Blood Pressure / drug effects*
Dogs
Ethanolamines / pharmacology*
Female
Femoral Artery / physiology
Heart Rate / drug effects
Isoproterenol / pharmacology
Kidney / blood supply
Labetalol / pharmacology*
Male
Phentolamine / pharmacology
Propranolol / pharmacology
Rats
Regional Blood Flow / drug effects
Vasomotor System / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Ethanolamines; 36894-69-6/Labetalol; 50-60-2/Phentolamine; 525-66-6/Propranolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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