Document Detail

Hypotensive mechanisms of antihypertensives based on the water tank model.
MedLine Citation:
PMID:  2757809     Owner:  NLM     Status:  MEDLINE    
Mechanisms of hypotensive action of antihypertensive drugs were theoretically considered using the water tank model on body fluid volume-blood pressure regulation. If a cock is attached to a tank with a base area corresponding to the reciprocal of total peripheral resistance (TPR) and water is poured into this tank at a rate corresponding to the amount of Na+ intake, then equilibrium should be achieved at a certain water level, volume, and output from the cock, which represent mean arterial pressure (MAP), cardiac output (CO), and urinary Na+ excretion rate. The height of the cock from the tank bottom and the size of the cock correspond to the x-intercept and slope of the renal function curve (pressure-natriuresis relationship). Vasodilators lowered the cock height and enlarged the base area (reduced TPR), resulting in an increase in the volume (CO). beta-Blockers not only lowered the height, but also decreased the size of the cock. Because they do not alter TPR (base area), CO (volume) must be reduced. Converting-enzyme inhibitors had the same effects on the height and size of the cock as beta-blockers, but enlarged the base area (reduced TPR), resulting in an increase in the volume (CO). Diuretics increased the cock size without affecting the cock height or the base area, resulting in a decrease in CO. The effects of antihypertensive drugs on the cock (kidney) seemed essential in their hypotensive action, similarly as abnormality of the renal function curve is essential in the genesis of hypertension. These analyses can illustrate schematically the hemodynamic changes induced by antihypertensive drugs.
G Kimura; H Abe; T Ashida; Y Kawano; H Yoshimi; M Imanishi; M Kawamura; S Kojima; K Yoshida; M Kuramochi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  2     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-13     Completed Date:  1989-09-13     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-6     Citation Subset:  IM    
Department of Medicine, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Body Fluids / physiology
Hypertension / drug therapy,  physiopathology
Models, Biological*
Reg. No./Substance:
0/Antihypertensive Agents

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