Document Detail

Hypotensive mechanism of potassium supplementation in salt-loaded patients with essential hypertension.
MedLine Citation:
PMID:  3869819     Owner:  NLM     Status:  MEDLINE    
To investigate the hypotensive mechanism of potassium supplementation, blood pressure responses and hormonal changes were measured during KCl supplementation in salt-loaded patients with essential hypertension. Ten patients with essential hypertension were placed on low sodium intake, high sodium intake, and high sodium intake with KCl supplementation. Blood pressure increased during NaCl loading and decreased during KCl supplementation. The levels of urinary sodium and fractional sodium excretion increased after KCl supplementation. Reduction in blood pressure after KCl supplementation was correlated with an increase in blood pressure after NaCl supplementation, i.e., potassium sensitivity and sodium sensitivity were correlated. Plasma PGE2 and norepinephrine increased after KCl loading. Increases in plasma PGE2 were correlated with a reduction of blood pressure by KCl. These results indicate that natriuresis and hypotensive action of KCl are associated with increased PGE2 production, and the sympathetic nerve activity suggests a compensatory increase for the decrease in blood pressure.
Y Tabuchi; T Ogihara; S Gotoh; K Masuo; K Hashizume; Y Kumahara
Related Documents :
6535339 - Return of hypertension after withdrawal of prolonged antihypertensive therapy, effect o...
10930059 - The effect of sodium bicarbonate on propranolol-induced cardiovascular toxicity in a ca...
1879839 - A controller for regulation of mean arterial blood pressure using optimum nitroprusside...
11675399 - Downstream shift in sodium pump activity along the nephron during acute hypertension.
6945939 - Abnormal erythrocyte na+ k+ cotransport system, a proposed genetic marker of essential ...
6741919 - Blood pressure and nutrition in adults. the national health and nutrition examination s...
1266599 - Intraosseous pressure in the femoral head and greater trochanter before and 1-3 years a...
19639519 - The effect of magnesium sulfate treatment on blood biochemistry and bleeding time in pa...
22951089 - Relationship of central and peripheral blood pressure to left ventricular mass in hyper...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension     Volume:  1     ISSN:  0748-450X     ISO Abbreviation:  J Clin Hypertens     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8510461     Medline TA:  J Clin Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Diet, Sodium-Restricted
Hormones / metabolism
Hypertension / metabolism*,  physiopathology
Hypotension / chemically induced*,  metabolism
Middle Aged
Norepinephrine / blood
Potassium / blood,  urine
Potassium Chloride / administration & dosage,  pharmacology*
Prostaglandins E / blood
Sodium / blood,  urine
Sodium Chloride / administration & dosage,  pharmacology*
Time Factors
Reg. No./Substance:
0/Hormones; 0/Prostaglandins E; 363-24-6/Dinoprostone; 51-41-2/Norepinephrine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative studies on the infestation of three different breeds of dogs by gastro-intestinal helmin...
Next Document:  Potentiation of histamine-induced microvascular permeability by prostaglandin E2 in rat mesentery.