Document Detail


Hypotensive mechanism of potassium supplementation in salt-loaded patients with essential hypertension.
MedLine Citation:
PMID:  3869819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the hypotensive mechanism of potassium supplementation, blood pressure responses and hormonal changes were measured during KCl supplementation in salt-loaded patients with essential hypertension. Ten patients with essential hypertension were placed on low sodium intake, high sodium intake, and high sodium intake with KCl supplementation. Blood pressure increased during NaCl loading and decreased during KCl supplementation. The levels of urinary sodium and fractional sodium excretion increased after KCl supplementation. Reduction in blood pressure after KCl supplementation was correlated with an increase in blood pressure after NaCl supplementation, i.e., potassium sensitivity and sodium sensitivity were correlated. Plasma PGE2 and norepinephrine increased after KCl loading. Increases in plasma PGE2 were correlated with a reduction of blood pressure by KCl. These results indicate that natriuresis and hypotensive action of KCl are associated with increased PGE2 production, and the sympathetic nerve activity suggests a compensatory increase for the decrease in blood pressure.
Authors:
Y Tabuchi; T Ogihara; S Gotoh; K Masuo; K Hashizume; Y Kumahara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension     Volume:  1     ISSN:  0748-450X     ISO Abbreviation:  J Clin Hypertens     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8510461     Medline TA:  J Clin Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Diet, Sodium-Restricted
Dinoprostone
Female
Hormones / metabolism
Humans
Hypertension / metabolism*,  physiopathology
Hypotension / chemically induced*,  metabolism
Male
Middle Aged
Norepinephrine / blood
Potassium / blood,  urine
Potassium Chloride / administration & dosage,  pharmacology*
Prostaglandins E / blood
Sodium / blood,  urine
Sodium Chloride / administration & dosage,  pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Hormones; 0/Prostaglandins E; 363-24-6/Dinoprostone; 51-41-2/Norepinephrine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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