| Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet. | |
| | |
MedLine Citation:
|
PMID: 21213397 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Morus alba L. has been used in traditional Chinese medicine and almost all parts of this plant are useful in cardiovascular, liver and spleen disorders. The present study was designed to investigate the inhibitory effect of a water extract from Morus alba L. (WMA) on vascular dysfunction in rat models fed a high fat and high cholesterol diet. Male rats were fed an atherogenic diet consisting of food with 7.5% cocoa butter and 1.25% cholesterol, with or without 100 or 200 mg/day/kg WMA, for 14 weeks. Chronic treatment with low (100 mg/kg/day) or high (200 mg/day/kg) doses of WMA markedly attenuated hypertension and the impairments of acetylcholine-induced relaxation of aortic rings in rats fed an atherogenic diet. WMA reduced intima/media thickness in rats fed an atherogenic diet. WMA improved plasma levels of triglyceride (TG) and augmented plasma levels of high-density lipoprotein (HDL) and plasma low-density lipoprotein (LDL), but did not affect blood glucose levels. Interestingly, WMA suppressed increased cell adhesion molecules such as E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intracellular adhesion molecule-1 (ICAM-1) expression in the aorta. Taken together, these results suggested that Morus alba L. could improve an atherogenic diet-induced hypertension, hyperlipidemia, and vascular dysfunction through inhibition of cell adhesion molecules expression and induction of vascular relaxation. |
| | |
Authors:
|
Yun Jung Lee; Deok Ho Choi; Eun Ju Kim; Hye Yoom Kim; Tae Oh Kwon; Dae Gill Kang; Ho Sub Lee |
Related Documents
:
|
16673767 - Performance and gastrointestinal tract metabolism of turkeys fed diets with different c... 20666857 - Replacement effects of panicum maximum with ficus polita on performance of west african... 10849867 - Selected animal and plant protein sources affect nutrient digestibility and fecal chara... 16050187 - Effects of beta-glucanase-producing lactobacillus strains on growth, dry matter and cru... 6403237 - Selenium and mouse mammary tumorigenesis: an investigation of possible mechanisms. 8949647 - Intestinal paracellular permeability during malnutrition in guinea pigs: effect of high... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of Chinese medicine Volume: 39 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: Singapore |
Other Details:
|
Languages: eng Pagination: 39-52 Citation Subset: IM |
Affiliation:
|
Professional Graduate School of Oriental Medicine, Wonkwang University, Jeonbuk, 570-749, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Active ear acupuncture points in neonates with neonatal abstinence syndrome (NAS).
Next Document: Anti-diabetic effects of a coptis chinensis containing new traditional chinese medicine formula in t...