Document Detail

Hypotensive effects of the lipoxygenase inhibitor phenidone in two-kidney, one clip Goldblatt hypertension.
MedLine Citation:
PMID:  2511900     Owner:  NLM     Status:  MEDLINE    
This study examined the role of the lipoxygenase (LO) pathway in the maintenance of hypertension in rats with two-kidney, one clip (2K,1C) Goldblatt hypertension. A single dose of the lipoxygenase blocker phenidone was injected intraperitoneally to 2K,1C rats during the early phase (14 days) of the development of hypertension (mean intraarterial blood pressure 137 +/- 3.9 mm Hg). Phenidone (60 mg/kg) markedly decreased arterial pressure to nadir levels of 58.9% of resting blood pressure. The maximal changes were observed 15 min after injection and the hypotensive response was sustained for at least 2 h. Plasma renin concentration (PRC) increased from 74.3 +/- 18.9 to 281.0 +/- 6.5 ng/mL/h after injection (P less than .05). Thus, the hypotensive effect of phenidone was not due to suppression of renin secretion but presumably due to inhibition of its effects. It is suggested that arachidonate metabolites of the LO pathway at the vascular bed may be involved in maintenance of high arterial pressure in 2K,1C renovascular hypertension in rat.
K Nozawa; M L Tuck; M Golub; P Eggena; J Nadler; N Stern
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  2     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-5     Citation Subset:  IM    
Division of Endocrinology, Sepulveda Veterans Administration Medical Center, California.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Blood Pressure / drug effects
Hypertension, Renovascular / drug therapy*,  physiopathology
Lipoxygenase Inhibitors
Pyrazoles / therapeutic use*
Rats, Inbred Strains
Renin / blood
Reg. No./Substance:
0/Arachidonic Acids; 0/Lipoxygenase Inhibitors; 0/Pyrazoles; 506-32-1/Arachidonic Acid; 92-43-3/phenidone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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