| Hypotensive effects of the Crotalus durissus cascavella venom: involvement of NO. | |
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MedLine Citation:
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PMID: 21815429 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Crotalus durissus cascavella is a snake native of northeastern Brazil. The aim of the study was to investigate the effects of C. d. cascavella venom on rat mean arterial pressure and vascular reactivity in the mesenteric vascular bed. The venom evoked a dose-dependent decrease in mean arterial pressure, cardiac and respiratory frequency with increased plasma nitrite levels. L-NAME (10 mg/kg) blunted both the hypotension and increased nitrite production observed after the venom administration. To investigate the effects of C. d. cascavella in resistance vessels, the vascular mesenteric bed was studied, and the results suggested that the hypotensive effect of the venom is not dependent on a direct vasodilatory activity. In conclusion, C. d. cascavella venom presented indirect hypotensive effects with the involvement of nitric oxide. |
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Authors:
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Janaina S A M Evangelista; João J F Evangelista; Inez L Evangelista; Diva M B Nojosa; Nilberto R F Nascimento; Marcellus H L P Souza; Renata S Alves; Alice M C Martins; Maria Elisabete A Moraes; Helena S A Monteiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 871-4 Citation Subset: IM |
Affiliation:
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Veterinary Faculty, Estadual University of Ceará, Fortaleza, Ceará, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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