Document Detail

Hypotensive effect of plasma exchange in immune complex nephritis.
MedLine Citation:
PMID:  3158296     Owner:  NLM     Status:  MEDLINE    
The effect of plasma exchange (PE) on blood pressure (BP) in 20 hypertensive patients (9 with mixed cryoglobulinemia, 7 with systemic lupus erythematosus, and 4 with idiopathic glomerulonephritis) was evaluated retrospectively. In each PE 1.5-2.5 L of plasma was replaced with an equal volume of 4% albumin polysaline solution. The frequency of PE was three times per week for the first 2 weeks and twice per week subsequently. Sixteen patients were on hypotensive treatment at the onset of PE. Their systolic/diastolic BP was 171 +/- 4.7/102 +/- 3.0 mm Hg (mean +/- 1 SEM). After 4 weeks, BP decreased to 141 +/- 2.8/89 +/- 2.3 mm Hg (p less than 0.001), although in 10 patients antihypertensive drug therapy had been reduced or discontinued. The most marked decrease of BP occurred after the first week (152 +/- 5.3/92 +/- 2.9 mm Hg), and this decrement correlated remarkably well with pressure levels before PE despite the great heterogeneity of the individual patients (for diastolic BP, r = 0.87, p less than 0.001; for systolic BP, r = 0.60, p less than 0.01). A mild decrease of serum creatinine was observed during PE, but its time course was different from that of BP, and did not correlate with this parameter.
R Puccini; E Fommei; P Meconi; L Moriconi; C Palombo; A Pasquariello; C Ferri; L Cioni; S Ghione
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  9     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
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MeSH Terms
Cryoglobulinemia / therapy
Glomerulonephritis / therapy
Hypertension / therapy*
Immune Complex Diseases / therapy*
Lupus Erythematosus, Systemic / therapy
Middle Aged
Nephritis / therapy*
Plasma Exchange*
Vasculitis / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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