| Hypotensive effect of long-term oral calcium supplementation in elderly patients with essential hypertension. | |
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MedLine Citation:
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PMID: 3097267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcium gluconate (22.4 g/day; 2 g/day as Ca) was administered orally for 8 weeks to eight hospitalized elderly patients with essential hypertension in order to confirm the hypotensive effect of oral calcium supplementation and to clarify its hypotensive mechanism by analyzing changes in hormonal factors. After 2 weeks of calcium supplementation, both systolic and diastolic pressures decreased significantly and remained decreased for the duration of the study. An elevation of plasma PGE2 correlated with blood pressure reduction was observed at 2 weeks. Plasma norepinephrine decreased significantly from 4 weeks. Plasma parathyroid hormone decreased significantly from 4 weeks, and 1,25-dihydroxyvitamin D (1,25-[OH]2D) decreased significantly at 8 weeks. The reduction of plasma 1,25-(OH)2D correlated with blood pressure decrease at 8 weeks. The present study indicates that the mechanism of its hypotensive effect is multifactorial and may be different during different phases of calcium supplementation. The suppression of plasma 1,25-(OH)2D following reduction of parathyroid hormone may be involved in the hypotensive effect in the chronic phase of calcium supplementation. Enhancement of PGE2 production in the early phase and suppression of sympathetic nervous activity in the chronic phase may also be factors in blood pressure reduction. |
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Authors:
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Y Tabuchi; T Ogihara; K Hashizume; H Saito; Y Kumahara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical hypertension Volume: 2 ISSN: 0748-450X ISO Abbreviation: J Clin Hypertens Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-08 Completed Date: 1987-01-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8510461 Medline TA: J Clin Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 254-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Blood Pressure / drug effects* Calcitriol / blood Calcium / blood Calcium Gluconate / therapeutic use* Female Gluconates / therapeutic use* Heart Rate / drug effects Humans Hypertension / drug therapy* Long-Term Care Male Parathyroid Hormone / blood |
| Chemical | |
Reg. No./Substance:
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0/Gluconates; 0/Parathyroid Hormone; 299-28-5/Calcium Gluconate; 32222-06-3/Calcitriol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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